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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 30.3
Human Site: Y491 Identified Species: 44.44
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 Y491 S L F P G T W Y L E R V D E Q
Chimpanzee Pan troglodytes XP_513693 508 56570 Y491 S L F P G T W Y L E R V D E Q
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 Y491 S L F P G T W Y L E R V D E L
Dog Lupus familis XP_849878 508 56870 Y491 S L F P G T W Y L E R V D E L
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 Y491 N L F P G T W Y L E R V D E M
Rat Rattus norvegicus P22791 508 56893 Y491 N L F P G T W Y L E R V D E M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 Y577 I L F P G T W Y L E Q V D T L
Chicken Gallus gallus P23228 522 57541 R503 S P A K K V P R I P A T T E S
Frog Xenopus laevis NP_001080399 520 57209 R503 S P A K K V P R I P P A A E A
Zebra Danio Brachydanio rerio NP_957379 508 55918 P492 L K K M P R I P T T T A G P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 L449 Y L K D V D A L H R R T Y E R
Honey Bee Apis mellifera XP_397202 453 50855 Y437 K N L F P G T Y Y L V Q V D E
Nematode Worm Caenorhab. elegans P54871 462 51397 T446 K L Y R R S Y T L H E E P N G
Sea Urchin Strong. purpuratus XP_801879 508 56054 Q484 Q Q A V D S Q Q I I Q E T L K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 R445 K E V D S L Y R R F Y G K K G
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 Y475 H L Q S G V Y Y L T N I D D K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 73.3 13.3 13.3 0 N.A. 20 6.6 13.3 0
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 80 20 20 6.6 N.A. 26.6 20 33.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 19 0 0 0 7 0 0 0 7 13 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 13 7 7 0 0 0 0 0 0 50 13 0 % D
% Glu: 0 7 0 0 0 0 0 0 0 44 7 13 0 57 13 % E
% Phe: 0 0 44 7 0 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 50 7 0 0 0 0 0 7 7 0 13 % G
% His: 7 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 7 0 19 7 0 7 0 0 0 % I
% Lys: 19 7 13 13 13 0 0 0 0 0 0 0 7 7 13 % K
% Leu: 7 63 7 0 0 7 0 7 57 7 0 0 0 7 19 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 13 % M
% Asn: 13 7 0 0 0 0 0 0 0 0 7 0 0 7 0 % N
% Pro: 0 13 0 44 13 0 13 7 0 13 7 0 7 7 0 % P
% Gln: 7 7 7 0 0 0 7 7 0 0 13 7 0 0 13 % Q
% Arg: 0 0 0 7 7 7 0 19 7 7 44 0 0 0 7 % R
% Ser: 38 0 0 7 7 13 0 0 0 0 0 0 0 0 7 % S
% Thr: 0 0 0 0 0 44 7 7 7 13 7 13 13 7 0 % T
% Val: 0 0 7 7 7 19 0 0 0 0 7 44 7 0 0 % V
% Trp: 0 0 0 0 0 0 44 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 0 19 57 7 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _