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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
24.83
Human Site:
Y503
Identified Species:
36.41
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y503
D
E
Q
H
R
R
K
Y
A
R
R
P
V
_
_
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y503
D
E
Q
H
R
R
K
Y
A
R
R
P
V
_
_
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y503
D
E
L
H
R
R
K
Y
A
R
R
P
I
_
_
Dog
Lupus familis
XP_849878
508
56870
Y503
D
E
L
Y
R
R
K
Y
A
R
R
P
V
_
_
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y503
D
E
M
H
R
R
K
Y
A
R
C
P
V
_
_
Rat
Rattus norvegicus
P22791
508
56893
Y503
D
E
M
H
R
R
K
Y
A
R
R
P
V
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
Y589
D
T
L
Y
R
R
K
Y
A
R
R
P
L
_
_
Chicken
Gallus gallus
P23228
522
57541
V515
T
E
S
E
G
V
T
V
A
I
S
N
G
V
H
Frog
Xenopus laevis
NP_001080399
520
57209
V515
A
E
A
E
P
I
S
V
T
N
G
E
H
_
_
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
Honey Bee
Apis mellifera
XP_397202
453
50855
Nematode Worm
Caenorhab. elegans
P54871
462
51397
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
V496
T
L
K
E
S
K
S
V
E
D
M
E
T
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
84.6
84.6
N.A.
84.6
92.3
N.A.
69.2
13.3
7.6
0
N.A.
0
0
0
0
P-Site Similarity:
100
100
92.3
92.3
N.A.
84.6
92.3
N.A.
84.6
13.3
7.6
0
N.A.
0
0
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
0
0
0
0
0
50
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
44
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% D
% Glu:
0
50
0
19
0
0
0
0
7
0
0
13
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
0
% G
% His:
0
0
0
32
0
0
0
0
0
0
0
0
7
0
7
% H
% Ile:
0
0
0
0
0
7
0
0
0
7
0
0
7
0
0
% I
% Lys:
0
0
7
0
0
7
44
0
0
0
0
0
0
0
0
% K
% Leu:
0
7
19
0
0
0
0
0
0
0
0
0
7
0
0
% L
% Met:
0
0
13
0
0
0
0
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
0
0
0
0
44
0
0
0
% P
% Gln:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
44
44
0
0
0
44
38
0
0
0
0
% R
% Ser:
0
0
7
0
7
0
13
0
0
0
7
0
0
0
0
% S
% Thr:
13
7
0
0
0
0
7
0
7
0
0
0
7
0
0
% T
% Val:
0
0
0
0
0
7
0
19
0
0
0
0
32
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
13
0
0
0
44
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
50
50
% _