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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AIF1
All Species:
20.61
Human Site:
S45
Identified Species:
50.37
UniProt:
P55008
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55008
NP_001614.3
147
16703
S45
S
S
D
E
D
L
P
S
K
L
E
G
F
K
E
Chimpanzee
Pan troglodytes
XP_001154743
147
16784
S45
S
S
D
E
D
L
P
S
K
L
E
G
F
K
E
Rhesus Macaque
Macaca mulatta
Q5TM25
147
16701
S45
S
S
D
E
D
L
L
S
K
L
E
G
F
K
E
Dog
Lupus familis
XP_849334
147
16728
S45
S
S
D
E
D
L
P
S
K
L
E
A
F
K
K
Cat
Felis silvestris
Mouse
Mus musculus
O70200
147
16892
S45
S
N
D
E
D
L
P
S
K
L
E
A
F
K
V
Rat
Rattus norvegicus
P55009
147
16809
S45
S
S
D
E
D
L
Q
S
K
L
E
A
F
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521721
160
17870
E57
S
D
E
E
D
L
E
E
K
L
A
A
F
K
E
Chicken
Gallus gallus
XP_415461
145
16272
E42
S
D
E
E
D
L
E
E
K
L
A
V
F
K
E
Frog
Xenopus laevis
NP_001085758
148
16998
K45
K
D
D
E
D
L
D
K
K
L
M
S
F
K
K
Zebra Danio
Brachydanio rerio
NP_942571
148
16914
E45
R
D
E
E
D
L
P
E
K
L
D
S
F
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
99.3
90.4
N.A.
89.1
89.8
N.A.
49.3
59.1
60.8
61.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
99.3
95.9
N.A.
94.5
93.1
N.A.
65
76.8
71.6
79.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
80
80
N.A.
60
60
53.3
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
86.6
80
N.A.
66.6
66.6
60
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
20
40
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
40
70
0
100
0
10
0
0
0
10
0
0
0
0
% D
% Glu:
0
0
30
100
0
0
20
30
0
0
60
0
0
0
50
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
30
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
0
0
0
10
100
0
0
0
0
100
20
% K
% Leu:
0
0
0
0
0
100
10
0
0
100
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
80
50
0
0
0
0
0
60
0
0
0
20
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _