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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
30
Human Site:
S149
Identified Species:
41.25
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
S149
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
S149
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
S228
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Dog
Lupus familis
XP_854659
425
48689
S149
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
S149
L
K
N
P
P
E
N
S
D
I
G
T
G
K
K
Rat
Rattus norvegicus
Q07205
429
48936
S149
L
K
N
P
P
E
N
S
D
I
G
T
G
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
S149
L
K
N
P
P
E
N
S
D
S
G
T
G
K
K
Chicken
Gallus gallus
NP_001006488
430
49060
G149
L
K
N
P
P
E
S
G
D
T
G
T
G
K
K
Frog
Xenopus laevis
NP_001080311
434
49605
T149
L
K
N
P
T
E
N
T
D
G
N
A
G
K
K
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
E149
L
K
N
P
P
E
N
E
S
G
S
V
K
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
N150
V
K
N
P
P
S
L
N
P
A
A
Q
G
S
S
Honey Bee
Apis mellifera
XP_392511
454
50921
N150
L
K
N
P
P
S
L
N
P
A
V
Q
G
S
S
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
D147
M
K
N
P
P
K
I
D
V
D
F
S
K
A
E
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
I140
H
K
L
S
T
F
I
I
K
N
P
P
E
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
K150
L
K
N
P
P
E
Q
K
K
G
G
K
D
K
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
K150
L
K
N
P
P
E
Q
K
K
S
S
K
D
K
K
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
V148
L
K
N
P
P
D
S
V
S
G
S
K
K
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
80
66.6
53.3
N.A.
33.3
40
26.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
93.3
73.3
60
N.A.
53.3
53.3
53.3
13.3
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
60
N.A.
60
46.6
N.A.
P-Site Similarity:
N.A.
60
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
12
6
6
0
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
6
0
6
53
6
0
0
12
0
6
% D
% Glu:
0
0
0
0
0
71
0
6
0
0
0
0
6
0
12
% E
% Phe:
0
0
0
0
0
6
0
0
0
0
6
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
6
0
24
53
0
65
0
0
% G
% His:
6
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% H
% Ile:
0
0
0
0
0
0
12
6
0
12
0
0
0
0
0
% I
% Lys:
0
100
0
0
0
6
0
12
18
0
0
18
18
77
71
% K
% Leu:
83
0
6
0
0
0
12
0
0
0
0
0
0
0
0
% L
% Met:
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
95
0
0
0
53
12
0
6
6
0
0
0
0
% N
% Pro:
0
0
0
95
89
0
0
0
12
0
6
6
0
0
0
% P
% Gln:
0
0
0
0
0
0
12
0
0
0
0
12
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
6
0
12
12
42
12
36
18
6
0
12
12
% S
% Thr:
0
0
0
0
12
0
0
6
0
6
0
48
0
0
0
% T
% Val:
6
0
0
0
0
0
0
6
6
0
6
6
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _