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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF5 All Species: 15.45
Human Site: S172 Identified Species: 21.25
UniProt: P55010 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55010 NP_001960.2 431 49223 S172 G K D K E N G S V S S S E T P
Chimpanzee Pan troglodytes XP_001135628 431 49234 S172 G K D K E N G S V S S S E T P
Rhesus Macaque Macaca mulatta XP_001086107 510 58170 S251 G K D K E N G S V S S S E T P
Dog Lupus familis XP_854659 425 48689 K168 K N R K G K D K E N G S R G R
Cat Felis silvestris
Mouse Mus musculus P59325 429 48950 N170 R K G K D K E N G S V S T S E
Rat Rattus norvegicus Q07205 429 48936 N170 R K G K D K E N G S V S T S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507766 428 48873 N170 R K G K D K E N G T V S S N E
Chicken Gallus gallus NP_001006488 430 49060 N170 R K G K D K E N G S V S S N E
Frog Xenopus laevis NP_001080311 434 49605 E169 N R K G K E K E N G S A A N E
Zebra Danio Brachydanio rerio NP_955885 429 49090 S170 K K D K E N G S N G G E A G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VXK6 464 51681 S177 K N D N A D G S M T N N S L A
Honey Bee Apis mellifera XP_392511 454 50921 T179 G E T T T T T T T A T A N G D
Nematode Worm Caenorhab. elegans Q22918 436 48768 A168 T S G A D A A A A V A A D I I
Sea Urchin Strong. purpuratus XP_787853 423 47400 K159 G S S K T E R K G K K S Q N K
Poplar Tree Populus trichocarpa
Maize Zea mays P55876 451 48894 A204 L K K K A T T A T G S D E D H
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C8F1 439 48604 K182 E E M R K L K K E A A S K K K
Baker's Yeast Sacchar. cerevisiae P38431 405 45243 G168 S A N V R G G G L S I S D I A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 75.8 93 N.A. 97.2 96.9 N.A. 94.9 92.8 83.4 76 N.A. 50.2 53.2 49.3 52.4
Protein Similarity: 100 99.7 80.1 95.1 N.A. 98.3 98.3 N.A. 97.6 96.7 91.9 89.5 N.A. 68 70.9 65.3 71.2
P-Site Identity: 100 100 100 13.3 N.A. 26.6 26.6 N.A. 20 26.6 6.6 46.6 N.A. 20 6.6 0 20
P-Site Similarity: 100 100 100 20 N.A. 46.6 46.6 N.A. 40 40 26.6 46.6 N.A. 53.3 40 33.3 26.6
Percent
Protein Identity: N.A. 30.3 N.A. 28.7 35.2 N.A.
Protein Similarity: N.A. 46.7 N.A. 47.3 53.1 N.A.
P-Site Identity: N.A. 26.6 N.A. 6.6 20 N.A.
P-Site Similarity: N.A. 33.3 N.A. 46.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 0 6 12 6 6 12 6 12 12 18 12 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 30 0 30 6 6 0 0 0 0 6 12 6 6 % D
% Glu: 6 12 0 0 24 12 24 6 12 0 0 6 24 0 30 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 30 0 30 6 6 6 36 6 30 18 12 0 0 18 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 6 0 0 12 6 % I
% Lys: 18 53 12 65 12 30 12 18 0 6 6 0 6 6 12 % K
% Leu: 6 0 0 0 0 6 0 0 6 0 0 0 0 6 0 % L
% Met: 0 0 6 0 0 0 0 0 6 0 0 0 0 0 0 % M
% Asn: 6 12 6 6 0 24 0 24 12 6 6 6 6 24 6 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 18 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 % Q
% Arg: 24 6 6 6 6 0 6 0 0 0 0 0 6 0 6 % R
% Ser: 6 12 6 0 0 0 0 30 0 42 30 65 18 12 0 % S
% Thr: 6 0 6 6 12 12 12 6 12 12 6 0 12 18 0 % T
% Val: 0 0 0 6 0 0 0 0 18 6 24 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _