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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
12.73
Human Site:
S175
Identified Species:
17.5
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
S175
K
E
N
G
S
V
S
S
S
E
T
P
P
P
P
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
S175
K
E
N
G
S
V
S
S
S
E
T
P
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
S254
K
E
N
G
S
V
S
S
S
E
T
P
P
P
P
Dog
Lupus familis
XP_854659
425
48689
G171
K
G
K
D
K
E
N
G
S
R
G
R
D
T
G
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
V173
K
D
K
E
N
G
S
V
S
T
S
E
T
P
P
Rat
Rattus norvegicus
Q07205
429
48936
V173
K
D
K
E
N
G
S
V
S
T
S
E
T
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
V173
K
D
K
E
N
G
T
V
S
S
N
E
T
T
P
Chicken
Gallus gallus
NP_001006488
430
49060
V173
K
D
K
E
N
G
S
V
S
S
N
E
T
P
P
Frog
Xenopus laevis
NP_001080311
434
49605
S172
G
K
E
K
E
N
G
S
A
A
N
E
S
P
V
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
G173
K
E
N
G
S
N
G
G
E
A
G
N
H
N
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
N180
N
A
D
G
S
M
T
N
N
S
L
A
N
N
S
Honey Bee
Apis mellifera
XP_392511
454
50921
T182
T
T
T
T
T
T
A
T
A
N
G
D
R
S
G
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
A171
A
D
A
A
A
A
V
A
A
D
I
I
H
N
S
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
K162
K
T
E
R
K
G
K
K
S
Q
N
K
Q
Q
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
S207
K
A
T
T
A
T
G
S
D
E
D
H
S
S
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
A185
R
K
L
K
K
E
A
A
S
K
K
K
A
A
T
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
I171
V
R
G
G
G
L
S
I
S
D
I
A
Q
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
100
13.3
N.A.
33.3
33.3
N.A.
20
33.3
13.3
33.3
N.A.
13.3
0
0
13.3
P-Site Similarity:
100
100
100
20
N.A.
53.3
53.3
N.A.
40
46.6
26.6
33.3
N.A.
46.6
26.6
33.3
20
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
20
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
12
6
6
12
6
12
12
18
12
0
12
6
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
30
6
6
0
0
0
0
6
12
6
6
6
0
6
% D
% Glu:
0
24
12
24
6
12
0
0
6
24
0
30
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
6
6
6
36
6
30
18
12
0
0
18
0
0
6
12
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
6
12
0
0
% H
% Ile:
0
0
0
0
0
0
0
6
0
0
12
6
0
0
0
% I
% Lys:
65
12
30
12
18
0
6
6
0
6
6
12
0
0
6
% K
% Leu:
0
0
6
0
0
6
0
0
0
0
6
0
0
0
0
% L
% Met:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
0
24
0
24
12
6
6
6
6
24
6
6
18
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
18
18
42
42
% P
% Gln:
0
0
0
0
0
0
0
0
0
6
0
0
12
6
0
% Q
% Arg:
6
6
0
6
0
0
0
0
0
6
0
6
6
0
0
% R
% Ser:
0
0
0
0
30
0
42
30
65
18
12
0
12
12
18
% S
% Thr:
6
12
12
12
6
12
12
6
0
12
18
0
24
12
6
% T
% Val:
6
0
0
0
0
18
6
24
0
0
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _