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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
38.79
Human Site:
S259
Identified Species:
53.33
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
S259
E
E
G
V
I
D
S
S
D
K
E
I
V
A
E
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
S259
E
E
G
V
I
D
S
S
D
K
E
I
V
A
E
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
S338
E
E
G
I
I
D
S
S
D
K
E
I
V
A
E
Dog
Lupus familis
XP_854659
425
48689
S253
E
E
G
I
I
D
S
S
D
K
E
I
V
A
E
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
S257
E
E
G
I
I
D
S
S
D
K
E
I
V
A
E
Rat
Rattus norvegicus
Q07205
429
48936
S257
E
E
G
I
I
D
S
S
D
K
D
I
V
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
S256
E
E
G
A
I
D
T
S
D
K
E
I
V
A
E
Chicken
Gallus gallus
NP_001006488
430
49060
S257
E
E
G
V
I
D
S
S
D
K
D
I
V
A
E
Frog
Xenopus laevis
NP_001080311
434
49605
C255
E
E
G
V
I
D
F
C
D
K
D
I
L
A
E
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
A252
D
S
G
T
I
D
S
A
D
K
D
I
L
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
T282
K
Q
L
D
D
V
Q
T
H
K
E
L
V
I
E
Honey Bee
Apis mellifera
XP_392511
454
50921
N273
R
D
A
G
Q
L
D
N
H
K
E
L
I
T
E
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
A252
Q
T
A
L
R
D
E
A
E
R
L
E
L
K
Q
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
C245
A
G
G
D
L
K
G
C
D
K
E
F
L
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
S284
K
D
G
S
T
N
G
S
A
K
E
I
P
N
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
G280
P
E
Q
V
H
E
N
G
N
S
K
I
P
E
N
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
Y251
E
L
T
Q
L
D
E
Y
G
E
W
I
L
E
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
86.6
N.A.
86.6
93.3
73.3
60
N.A.
26.6
20
6.6
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
86.6
86.6
N.A.
53.3
46.6
53.3
46.6
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
33.3
N.A.
20
20
N.A.
P-Site Similarity:
N.A.
60
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
12
6
0
0
0
12
6
0
0
0
0
59
0
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% C
% Asp:
6
12
0
12
6
71
6
0
65
0
24
0
0
0
6
% D
% Glu:
59
59
0
0
0
6
12
0
6
6
59
6
0
12
77
% E
% Phe:
0
0
0
0
0
0
6
0
0
0
0
6
0
0
0
% F
% Gly:
0
6
71
6
0
0
12
6
6
0
0
0
0
0
0
% G
% His:
0
0
0
0
6
0
0
0
12
0
0
0
0
0
0
% H
% Ile:
0
0
0
24
59
0
0
0
0
0
0
77
6
6
0
% I
% Lys:
12
0
0
0
0
6
0
0
0
83
6
0
0
6
0
% K
% Leu:
0
6
6
6
12
6
0
0
0
0
6
12
30
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
6
6
6
6
0
0
0
0
6
6
% N
% Pro:
6
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% P
% Gln:
6
6
6
6
6
0
6
0
0
0
0
0
0
0
12
% Q
% Arg:
6
0
0
0
6
0
0
0
0
6
0
0
0
0
0
% R
% Ser:
0
6
0
6
0
0
48
53
0
6
0
0
0
0
0
% S
% Thr:
0
6
6
6
6
0
6
6
0
0
0
0
0
6
0
% T
% Val:
0
0
0
30
0
6
0
0
0
0
0
0
53
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _