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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
38.48
Human Site:
S353
Identified Species:
52.92
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
S353
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
S353
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
S432
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Dog
Lupus familis
XP_854659
425
48689
S347
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
S351
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Rat
Rattus norvegicus
Q07205
429
48936
S351
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
S350
L
E
E
E
V
I
I
S
W
S
E
K
A
S
K
Chicken
Gallus gallus
NP_001006488
430
49060
G351
L
E
E
E
V
I
L
G
W
A
E
K
A
S
K
Frog
Xenopus laevis
NP_001080311
434
49605
S349
L
E
E
E
V
I
I
S
W
A
E
K
P
S
K
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
A346
V
E
E
D
V
I
L
A
W
A
E
K
V
S
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
E376
L
D
E
A
V
I
L
E
W
A
Q
K
V
S
K
Honey Bee
Apis mellifera
XP_392511
454
50921
E367
L
E
E
K
A
L
F
E
W
S
N
K
V
T
K
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
S340
C
E
E
D
S
L
I
S
W
G
E
K
P
S
S
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
T339
I
D
E
D
V
I
L
T
W
A
A
K
P
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
V376
E
G
A
Q
T
L
L
V
Q
A
I
E
A
F
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
E373
M
G
L
L
N
G
I
E
S
F
C
M
K
A
S
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
P341
L
E
H
K
D
L
I
P
L
L
P
K
I
L
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
80
86.6
60
N.A.
53.3
46.6
53.3
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
80
66.6
66.6
86.6
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
40
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
6
6
0
0
6
0
36
6
0
53
6
0
% A
% Cys:
6
0
0
0
0
0
0
0
0
0
6
0
0
0
0
% C
% Asp:
0
12
0
18
6
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
6
77
83
53
0
0
0
18
0
0
65
6
0
0
0
% E
% Phe:
0
0
0
0
0
0
6
0
0
6
0
0
0
6
0
% F
% Gly:
0
12
0
0
0
6
0
6
0
6
0
0
0
0
6
% G
% His:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
6
0
0
0
0
71
65
0
0
0
6
0
6
0
0
% I
% Lys:
0
0
0
12
0
0
0
0
0
0
0
89
6
0
77
% K
% Leu:
71
0
6
6
0
24
30
0
6
6
0
0
0
6
0
% L
% Met:
6
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% M
% Asn:
0
0
0
0
6
0
0
0
0
0
6
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
6
0
0
6
0
18
0
0
% P
% Gln:
0
0
0
6
0
0
0
0
6
0
6
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
6
0
0
53
6
48
0
0
0
77
12
% S
% Thr:
0
0
0
0
6
0
0
6
0
0
0
0
0
6
0
% T
% Val:
6
0
0
0
71
0
0
6
0
0
0
0
18
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
83
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _