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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF5
All Species:
33.94
Human Site:
S419
Identified Species:
46.67
UniProt:
P55010
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55010
NP_001960.2
431
49223
S419
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Chimpanzee
Pan troglodytes
XP_001135628
431
49234
S419
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Rhesus Macaque
Macaca mulatta
XP_001086107
510
58170
S498
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Dog
Lupus familis
XP_854659
425
48689
S413
P
K
V
E
A
V
K
S
D
N
K
D
D
D
I
Cat
Felis silvestris
Mouse
Mus musculus
P59325
429
48950
S417
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Rat
Rattus norvegicus
Q07205
429
48936
S417
P
K
V
E
T
V
K
S
D
N
K
D
D
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507766
428
48873
S415
P
K
V
E
T
V
K
S
A
G
N
K
E
D
D
Chicken
Gallus gallus
NP_001006488
430
49060
P417
P
K
V
E
T
V
K
P
A
N
N
K
D
D
D
Frog
Xenopus laevis
NP_001080311
434
49605
S421
P
K
V
E
A
V
K
S
P
V
D
K
D
D
D
Zebra Danio
Brachydanio rerio
NP_955885
429
49090
P414
L
K
M
E
T
T
K
P
A
K
A
E
H
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXK6
464
51681
Q442
R
G
G
Q
R
V
V
Q
R
G
I
P
R
A
V
Honey Bee
Apis mellifera
XP_392511
454
50921
N440
M
Q
K
P
A
V
V
N
E
D
S
D
D
E
D
Nematode Worm
Caenorhab. elegans
Q22918
436
48768
A414
A
Q
Q
K
S
A
K
A
T
N
G
N
A
A
A
Sea Urchin
Strong. purpuratus
XP_787853
423
47400
V395
R
G
G
A
G
L
K
V
E
T
T
E
P
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P55876
451
48894
S444
E
W
L
Q
S
A
E
S
D
E
E
G
D
D
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C8F1
439
48604
N431
P
F
I
E
W
L
Q
N
A
E
S
E
S
E
E
Baker's Yeast
Sacchar. cerevisiae
P38431
405
45243
S397
T
W
L
E
T
A
E
S
D
D
D
E
E
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
75.8
93
N.A.
97.2
96.9
N.A.
94.9
92.8
83.4
76
N.A.
50.2
53.2
49.3
52.4
Protein Similarity:
100
99.7
80.1
95.1
N.A.
98.3
98.3
N.A.
97.6
96.7
91.9
89.5
N.A.
68
70.9
65.3
71.2
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
60
66.6
60
26.6
N.A.
6.6
20
13.3
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
66.6
66.6
60
46.6
N.A.
20
53.3
46.6
26.6
Percent
Protein Identity:
N.A.
30.3
N.A.
28.7
35.2
N.A.
Protein Similarity:
N.A.
46.7
N.A.
47.3
53.1
N.A.
P-Site Identity:
N.A.
26.6
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
60
N.A.
53.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
0
6
18
18
0
6
24
0
6
0
6
12
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
48
12
12
42
59
65
30
% D
% Glu:
6
0
0
71
0
0
12
0
12
12
6
24
12
18
18
% E
% Phe:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
12
0
6
0
0
0
0
12
6
6
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% H
% Ile:
0
0
6
0
0
0
0
0
0
0
6
0
0
0
36
% I
% Lys:
0
59
6
6
0
0
71
0
0
6
36
18
0
6
6
% K
% Leu:
6
0
12
0
0
12
0
0
0
0
0
0
0
0
0
% L
% Met:
6
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
12
0
48
12
6
0
0
0
% N
% Pro:
59
0
0
6
0
0
0
12
6
0
0
6
6
0
0
% P
% Gln:
0
12
6
12
0
0
6
6
0
0
0
0
0
0
0
% Q
% Arg:
12
0
0
0
6
0
0
0
6
0
0
0
6
0
0
% R
% Ser:
0
0
0
0
12
0
0
59
0
0
12
0
6
0
0
% S
% Thr:
6
0
0
0
53
6
0
0
6
6
6
0
0
0
0
% T
% Val:
0
0
53
0
0
65
12
6
0
6
0
0
0
0
6
% V
% Trp:
0
12
0
0
6
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _