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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DRG2 All Species: 22.73
Human Site: S49 Identified Species: 35.71
UniProt: P55039 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55039 NP_001379.1 364 40746 S49 L E P S K S A S S K G E G F D
Chimpanzee Pan troglodytes XP_001158439 343 38111 S49 L E P S K S A S S K G E G F D
Rhesus Macaque Macaca mulatta XP_001093452 343 38083 S49 L E P S K S A S S K G E G F D
Dog Lupus familis XP_536661 364 40714 S49 L E P S K S A S S K G E G F D
Cat Felis silvestris
Mouse Mus musculus Q9QXB9 364 40700 S49 L E P S K S A S S K G E G F D
Rat Rattus norvegicus XP_001076012 364 40701 S49 L E P S K S A S S K G E G F D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512784 296 33355
Chicken Gallus gallus NP_001025805 364 40687 A49 L E P S K S S A A K G E G F D
Frog Xenopus laevis P43690 367 40396 G51 T P K G G G G G G P G E G F D
Zebra Danio Brachydanio rerio NP_997803 364 40863 G49 L E P S K S A G A K G E G F D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P32234 368 41113 G51 S P K G G G G G T G E A G F E
Honey Bee Apis mellifera XP_624466 363 40827 E49 L E P P K K S E K G E G F D V
Nematode Worm Caenorhab. elegans P34280 366 40804 G49 L E P T G K G G A K G E G F D
Sea Urchin Strong. purpuratus XP_790752 363 41012 G49 L E P T G K S G A K G E G F D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53295 368 40987 G50 A D E A G S G G G G G S G F E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.7 92 99.7 N.A. 98.6 98 N.A. 73 96.9 56.6 91.4 N.A. 58.4 84 75.1 74.7
Protein Similarity: 100 92.5 92.3 100 N.A. 100 99.7 N.A. 77.1 99.1 71.6 96.4 N.A. 72 90.3 86 85.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 80 33.3 86.6 N.A. 13.3 26.6 60 60
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 100 33.3 93.3 N.A. 26.6 33.3 73.3 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 58.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 77.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 7 0 0 47 7 27 0 0 7 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 0 0 0 7 74 % D
% Glu: 0 74 7 0 0 0 0 7 0 0 14 74 0 0 14 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 87 0 % F
% Gly: 0 0 0 14 34 14 27 40 14 20 80 7 87 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 14 0 60 20 0 0 7 67 0 0 0 0 0 % K
% Leu: 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 14 74 7 0 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 7 0 0 54 0 60 20 40 40 0 0 7 0 0 0 % S
% Thr: 7 0 0 14 0 0 0 0 7 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _