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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VCP All Species: 42.73
Human Site: S652 Identified Species: 78.33
UniProt: P55072 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55072 NP_009057.1 806 89322 S652 I P L P D E K S R V A I L K A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852626 806 89284 S652 I P L P D E K S R V A I L K A
Cat Felis silvestris
Mouse Mus musculus Q3UMC0 893 97237 A746 S S G A G N V A D R V L A Q L
Rat Rattus norvegicus P46462 806 89330 S652 I P L P D E K S R V A I L K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520419 805 89553 S651 I P L P D E K S R V A I L K A
Chicken Gallus gallus NP_001038129 806 89306 S652 I P L P D E K S R V A I L K A
Frog Xenopus laevis P23787 805 89193 S652 I P L P D E K S R M A I L K A
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 S652 I P L P D E K S R I A I L K A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 S649 I P L P D D K S R E A I L K A
Honey Bee Apis mellifera XP_392892 800 88877 S649 I P L P D E K S R E A I F R A
Nematode Worm Caenorhab. elegans P54812 810 89622 S657 I P L P D E A S R L Q I F K A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LZF6 810 89940 S655 I P L P D E D S R L N I F K A
Baker's Yeast Sacchar. cerevisiae P25694 835 91977 A662 V P L P D E N A R L S I L N A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 99.8 N.A. 38.5 99.8 N.A. 97.8 99 96.6 96.7 N.A. 83.1 83.6 78.7 N.A.
Protein Similarity: 100 N.A. N.A. 99.8 N.A. 57.1 100 N.A. 98.3 99.7 98.8 98.7 N.A. 92 93 89.2 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 0 100 N.A. 100 100 93.3 93.3 N.A. 86.6 80 73.3 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 20 100 N.A. 100 100 100 100 N.A. 93.3 86.6 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 77.1 67.5 N.A.
Protein Similarity: N.A. N.A. N.A. 87.6 83.2 N.A.
P-Site Identity: N.A. N.A. N.A. 73.3 60 N.A.
P-Site Similarity: N.A. N.A. N.A. 80 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 16 0 0 70 0 8 0 93 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 93 8 8 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 85 0 0 0 16 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 % F
% Gly: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 85 0 0 0 0 0 0 0 0 8 0 93 0 0 0 % I
% Lys: 0 0 0 0 0 0 70 0 0 0 0 0 0 77 0 % K
% Leu: 0 0 93 0 0 0 0 0 0 24 0 8 70 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 8 0 0 0 8 0 0 8 0 % N
% Pro: 0 93 0 93 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 93 8 0 0 0 8 0 % R
% Ser: 8 8 0 0 0 0 0 85 0 0 8 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 0 0 8 0 0 39 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _