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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AQP4
All Species:
28.48
Human Site:
Y277
Identified Species:
52.22
UniProt:
P55087
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55087
NP_001641.1
323
34830
Y277
A
Q
Q
T
K
G
S
Y
M
E
V
E
D
N
R
Chimpanzee
Pan troglodytes
XP_512074
323
34825
Y277
A
Q
Q
T
K
G
S
Y
M
E
V
E
D
N
R
Rhesus Macaque
Macaca mulatta
XP_001097418
323
34819
Y277
A
Q
Q
T
K
G
S
Y
M
E
V
E
D
N
R
Dog
Lupus familis
XP_855456
398
42980
Y352
T
Q
Q
T
K
R
S
Y
M
E
V
E
D
N
R
Cat
Felis silvestris
Mouse
Mus musculus
P55088
323
34418
Y277
A
Q
Q
T
K
G
S
Y
M
E
V
E
D
N
R
Rat
Rattus norvegicus
P47863
323
34462
Y277
A
Q
Q
T
K
G
S
Y
M
E
V
E
D
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505227
324
34855
Y278
A
Q
P
A
K
G
H
Y
V
E
V
D
N
S
Q
Chicken
Gallus gallus
P28238
262
27053
S229
A
L
C
P
R
A
R
S
M
A
E
R
L
A
V
Frog
Xenopus laevis
NP_001124421
295
31792
S262
Y
K
E
V
E
E
K
S
Q
L
D
S
D
D
L
Zebra Danio
Brachydanio rerio
NP_001003749
320
34409
R279
P
F
Q
M
E
P
Y
R
V
V
D
T
D
S
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V5Z7
245
25557
Y212
V
W
T
Y
H
W
V
Y
W
V
G
P
I
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193877
295
31953
R262
T
D
K
A
A
I
S
R
L
T
S
C
C
C
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZVX8
278
29482
G245
D
H
W
I
F
W
V
G
P
F
V
G
A
L
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
77.6
N.A.
92.8
94.1
N.A.
84.8
38.3
69.9
61.6
N.A.
35.5
N.A.
N.A.
38.7
Protein Similarity:
100
100
99.6
79.4
N.A.
95.3
96.5
N.A.
92.9
55.1
79.2
76.1
N.A.
48.6
N.A.
N.A.
55.1
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
46.6
13.3
6.6
13.3
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
80
20
33.3
33.3
N.A.
6.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
50.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
54
0
0
16
8
8
0
0
0
8
0
0
8
16
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
8
8
8
0
% C
% Asp:
8
8
0
0
0
0
0
0
0
0
16
8
62
8
0
% D
% Glu:
0
0
8
0
16
8
0
0
0
54
8
47
0
0
0
% E
% Phe:
0
8
0
0
8
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
47
0
8
0
0
8
8
0
0
8
% G
% His:
0
8
0
0
8
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
8
8
0
54
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
8
8
0
0
8
8
8
% L
% Met:
0
0
0
8
0
0
0
0
54
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
47
0
% N
% Pro:
8
0
8
8
0
8
0
0
8
0
0
8
0
0
0
% P
% Gln:
0
54
54
0
0
0
0
0
8
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
8
8
8
16
0
0
0
8
0
0
54
% R
% Ser:
0
0
0
0
0
0
54
16
0
0
8
8
0
16
0
% S
% Thr:
16
0
8
47
0
0
0
0
0
8
0
8
0
0
0
% T
% Val:
8
0
0
8
0
0
16
0
16
16
62
0
0
0
8
% V
% Trp:
0
8
8
0
0
16
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
8
62
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _