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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASP7 All Species: 13.64
Human Site: S34 Identified Species: 25
UniProt: P55210 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55210 NP_001218.1 303 34277 S34 D R S S F V P S L F S K K K K
Chimpanzee Pan troglodytes Q5IS54 277 31588 K19 S I K N L E P K I I H G S Q S
Rhesus Macaque Macaca mulatta XP_001090833 303 33954 S34 D R S S L I P S L L S K K K K
Dog Lupus familis XP_544026 359 40231 S92 D R S S F V P S L F S R K K K
Cat Felis silvestris
Mouse Mus musculus P97864 303 34042 S34 D R S S I I S S I L L K K K R
Rat Rattus norvegicus P55213 277 31473 K19 S I N N F E T K T I H G S K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513388 306 34477 K39 K V A Q L F S K K K N E A E S
Chicken Gallus gallus Q98943 424 47941 M32 E L V L K E L M E H M I E K D
Frog Xenopus laevis P55866 282 32106 Q24 A K E Y F T I Q P R S L Q N C
Zebra Danio Brachydanio rerio NP_001018443 316 35890 F45 R F R L F G N F K K N D G K L
Tiger Blowfish Takifugu rubipres NP_001027871 280 30520 Q22 A K K G A G Q Q S G S S S G R
Fruit Fly Dros. melanogaster O01382 339 37345 A45 A G S S G L V A G S S H P Y G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42573 503 56598 S138 D S V S S V S S F T S Y Q D I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.1 94.7 73.5 N.A. 82.1 49.1 N.A. 64.7 23.8 47.8 64.2 50.8 35.6 N.A. 23.6 N.A.
Protein Similarity: 100 65.6 98 80.2 N.A. 90.7 65 N.A. 76.1 40 63.7 75.6 66.3 53 N.A. 38.9 N.A.
P-Site Identity: 100 6.6 80 93.3 N.A. 53.3 13.3 N.A. 0 6.6 13.3 13.3 6.6 20 N.A. 33.3 N.A.
P-Site Similarity: 100 26.6 86.6 100 N.A. 73.3 26.6 N.A. 26.6 20 26.6 20 20 33.3 N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 0 8 0 8 0 0 8 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 39 0 0 0 0 0 0 0 0 0 0 8 0 8 8 % D
% Glu: 8 0 8 0 0 24 0 0 8 0 0 8 8 8 0 % E
% Phe: 0 8 0 0 39 8 0 8 8 16 0 0 0 0 0 % F
% Gly: 0 8 0 8 8 16 0 0 8 8 0 16 8 8 8 % G
% His: 0 0 0 0 0 0 0 0 0 8 16 8 0 0 0 % H
% Ile: 0 16 0 0 8 16 8 0 16 16 0 8 0 0 8 % I
% Lys: 8 16 16 0 8 0 0 24 16 16 0 24 31 54 24 % K
% Leu: 0 8 0 16 24 8 8 0 24 16 8 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % M
% Asn: 0 0 8 16 0 0 8 0 0 0 16 0 0 8 0 % N
% Pro: 0 0 0 0 0 0 31 0 8 0 0 0 8 0 0 % P
% Gln: 0 0 0 8 0 0 8 16 0 0 0 0 16 8 0 % Q
% Arg: 8 31 8 0 0 0 0 0 0 8 0 8 0 0 16 % R
% Ser: 16 8 39 47 8 0 24 39 8 8 54 8 24 0 24 % S
% Thr: 0 0 0 0 0 8 8 0 8 8 0 0 0 0 0 % T
% Val: 0 8 16 0 0 24 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _