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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASP9 All Species: 25.15
Human Site: Y363 Identified Species: 46.11
UniProt: P55211 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55211 NP_001220.2 416 46281 Y363 D P K S G S W Y V E T L D D I
Chimpanzee Pan troglodytes Q5IS54 277 31588 D228 A M L K Q Y A D K L E F M H I
Rhesus Macaque Macaca mulatta XP_001082859 416 46192 Y363 D P K S G S W Y I E T L D N I
Dog Lupus familis XP_865164 414 45235 Y362 N T K S G S W Y V E T L D G V
Cat Felis silvestris
Mouse Mus musculus P29594 452 50642 Y386 N T K R G S W Y I E A L T Q V
Rat Rattus norvegicus P55215 452 50709 Y386 N T K R G S W Y I E A L T Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520982 366 40213 Y313 D T Q S G S W Y I E T L D S V
Chicken Gallus gallus Q98943 424 47941 Y357 N T K R G S W Y I E A L T T V
Frog Xenopus laevis P55866 282 32106 M233 F I Q S L C K M I K L Y G S H
Zebra Danio Brachydanio rerio NP_001007405 436 48445 Y378 D T E A G S W Y V E N L D R V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02002 323 35908 T274 Y D L L T L L T F V N Q R V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42573 503 56598 F437 N S A R G S W F I Q A V C E V
Sea Urchin Strong. purpuratus XP_799258 437 48470 F377 N A E R G S W F I Q A L T E T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22.8 93.9 76.9 N.A. 28.9 28.3 N.A. 52.8 31.1 22.6 47.2 N.A. 22.1 N.A. 21.6 32.2
Protein Similarity: 100 35.8 96.8 84.1 N.A. 46.9 46.2 N.A. 65.6 48.3 38.7 64.2 N.A. 35.8 N.A. 37.5 51
P-Site Identity: 100 6.6 86.6 73.3 N.A. 46.6 46.6 N.A. 66.6 46.6 6.6 60 N.A. 0 N.A. 20 26.6
P-Site Similarity: 100 6.6 100 86.6 N.A. 66.6 66.6 N.A. 86.6 66.6 26.6 80 N.A. 0 N.A. 66.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 8 0 0 8 0 0 0 39 0 0 0 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % C
% Asp: 31 8 0 0 0 0 0 8 0 0 0 0 39 8 0 % D
% Glu: 0 0 16 0 0 0 0 0 0 62 8 0 0 16 0 % E
% Phe: 8 0 0 0 0 0 0 16 8 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 77 0 0 0 0 0 0 0 8 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % H
% Ile: 0 8 0 0 0 0 0 0 62 0 0 0 0 0 24 % I
% Lys: 0 0 47 8 0 0 8 0 8 8 0 0 0 0 0 % K
% Leu: 0 0 16 8 8 8 8 0 0 8 8 70 0 0 0 % L
% Met: 0 8 0 0 0 0 0 8 0 0 0 0 8 0 0 % M
% Asn: 47 0 0 0 0 0 0 0 0 0 16 0 0 8 0 % N
% Pro: 0 16 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 16 0 8 0 0 0 0 16 0 8 0 16 0 % Q
% Arg: 0 0 0 39 0 0 0 0 0 0 0 0 8 8 0 % R
% Ser: 0 8 0 39 0 77 0 0 0 0 0 0 0 16 0 % S
% Thr: 0 47 0 0 8 0 0 8 0 0 31 0 31 8 8 % T
% Val: 0 0 0 0 0 0 0 0 24 8 0 8 0 8 54 % V
% Trp: 0 0 0 0 0 0 77 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 8 0 62 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _