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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPEPPS All Species: 13.94
Human Site: S39 Identified Species: 23.59
UniProt: P55786 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55786 NP_006301.3 919 103276 S39 S S R R R L H S L G L A A M P
Chimpanzee Pan troglodytes XP_001173625 915 102923 S35 S S R R R L H S L G L A A M P
Rhesus Macaque Macaca mulatta XP_001082709 805 90718 T29 T L Q T G T G T L K I D F V G
Dog Lupus familis XP_537659 837 94265 E32 Y A P E G D E E I H A T G F N
Cat Felis silvestris
Mouse Mus musculus Q11011 920 103333 S40 R R R R R L H S L G L A A M P
Rat Rattus norvegicus Q9JJ22 930 106401 N32 T A S P K A S N G A S F P W N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234986 855 96195 C32 T N Q I V M N C A D I D I I T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001157499 872 98035 G34 L V D F T F E G K L E A A V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728614 1075 122740 T170 Y R A I L A H T S A D V I P G
Honey Bee Apis mellifera XP_394245 867 98542 D35 N L K T F V F D G K E D V H I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188563 781 87435
Poplar Tree Populus trichocarpa XP_002308539 857 96803 A36 R L K P E L T A C T F A G S V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195035 879 98160 T35 I A C T F T G T V A I D L D I
Baker's Yeast Sacchar. cerevisiae P32454 935 105566 S90 C A K C Q K T S Q L L N K T P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 87.4 90.2 N.A. 97 32.5 N.A. N.A. 84.3 N.A. 80.9 N.A. 47.9 53.5 N.A. 54.3
Protein Similarity: 100 97.7 87.4 90.5 N.A. 98.4 50.9 N.A. N.A. 88.2 N.A. 88 N.A. 61.1 68.5 N.A. 65.5
P-Site Identity: 100 100 6.6 0 N.A. 86.6 0 N.A. N.A. 0 N.A. 13.3 N.A. 6.6 0 N.A. 0
P-Site Similarity: 100 100 40 13.3 N.A. 86.6 26.6 N.A. N.A. 46.6 N.A. 20 N.A. 13.3 20 N.A. 0
Percent
Protein Identity: 42.7 N.A. N.A. 42.9 35.4 N.A.
Protein Similarity: 58.5 N.A. N.A. 58.9 53.9 N.A.
P-Site Identity: 13.3 N.A. N.A. 0 20 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 29 8 0 0 15 0 8 8 22 8 36 29 0 0 % A
% Cys: 8 0 8 8 0 0 0 8 8 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 8 0 8 0 8 8 29 0 8 0 % D
% Glu: 0 0 0 8 8 0 15 8 0 0 15 0 0 0 8 % E
% Phe: 0 0 0 8 15 8 8 0 0 0 8 8 8 8 0 % F
% Gly: 0 0 0 0 15 0 15 8 15 22 0 0 15 0 15 % G
% His: 0 0 0 0 0 0 29 0 0 8 0 0 0 8 0 % H
% Ile: 8 0 0 15 0 0 0 0 8 0 22 0 15 8 15 % I
% Lys: 0 0 22 0 8 8 0 0 8 15 0 0 8 0 0 % K
% Leu: 8 22 0 0 8 29 0 0 29 15 29 0 8 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 22 0 % M
% Asn: 8 8 0 0 0 0 8 8 0 0 0 8 0 0 15 % N
% Pro: 0 0 8 15 0 0 0 0 0 0 0 0 8 8 29 % P
% Gln: 0 0 15 0 8 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 15 15 22 22 22 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 15 15 8 0 0 0 8 29 8 0 8 0 0 8 0 % S
% Thr: 22 0 0 22 8 15 15 22 0 8 0 8 0 8 8 % T
% Val: 0 8 0 0 8 8 0 0 8 0 0 8 8 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _