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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPEPPS All Species: 24.55
Human Site: T750 Identified Species: 41.54
UniProt: P55786 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55786 NP_006301.3 919 103276 T750 L R S P V Y L T V L K H G D G
Chimpanzee Pan troglodytes XP_001173625 915 102923 T746 L R S P V Y L T V L K H G D G
Rhesus Macaque Macaca mulatta XP_001082709 805 90718 N663 A D M Q E E K N R I E R V L G
Dog Lupus familis XP_537659 837 94265 T668 L R S P V Y L T V L K H G D G
Cat Felis silvestris
Mouse Mus musculus Q11011 920 103333 T751 L R S P V Y L T V L K H G D G
Rat Rattus norvegicus Q9JJ22 930 106401 V763 V T L A V F A V G A Q N T E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234986 855 96195 T685 L R S P V Y V T I L K H G D S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001157499 872 98035 T705 L R S P V Y L T V L K H G D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728614 1075 122740 A913 L R T T C Y K A V L Q D G D E
Honey Bee Apis mellifera XP_394245 867 98542 A705 L R S P V Y R A V L S V G D T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188563 781 87435 K639 F A K Q L F G K V Y A S L G W
Poplar Tree Populus trichocarpa XP_002308539 857 96803 A688 E A S R R F H A F L E D R N T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195035 879 98160 A712 I R R A A Y V A V M Q R A N K
Baker's Yeast Sacchar. cerevisiae P32454 935 105566 T787 I K P I V F N T V A R V G G A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 87.4 90.2 N.A. 97 32.5 N.A. N.A. 84.3 N.A. 80.9 N.A. 47.9 53.5 N.A. 54.3
Protein Similarity: 100 97.7 87.4 90.5 N.A. 98.4 50.9 N.A. N.A. 88.2 N.A. 88 N.A. 61.1 68.5 N.A. 65.5
P-Site Identity: 100 100 6.6 100 N.A. 100 13.3 N.A. N.A. 80 N.A. 93.3 N.A. 46.6 66.6 N.A. 6.6
P-Site Similarity: 100 100 20 100 N.A. 100 46.6 N.A. N.A. 93.3 N.A. 93.3 N.A. 60 66.6 N.A. 20
Percent
Protein Identity: 42.7 N.A. N.A. 42.9 35.4 N.A.
Protein Similarity: 58.5 N.A. N.A. 58.9 53.9 N.A.
P-Site Identity: 13.3 N.A. N.A. 20 26.6 N.A.
P-Site Similarity: 33.3 N.A. N.A. 53.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 0 15 8 0 8 29 0 15 8 0 8 0 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 0 0 15 0 58 0 % D
% Glu: 8 0 0 0 8 8 0 0 0 0 15 0 0 8 8 % E
% Phe: 8 0 0 0 0 29 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 8 0 0 0 65 15 43 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 43 0 0 0 % H
% Ile: 15 0 0 8 0 0 0 0 8 8 0 0 0 0 0 % I
% Lys: 0 8 8 0 0 0 15 8 0 0 43 0 0 0 8 % K
% Leu: 58 0 8 0 8 0 36 0 0 65 0 0 8 8 0 % L
% Met: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 8 0 0 0 8 0 15 0 % N
% Pro: 0 0 8 50 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 15 0 0 0 0 0 0 22 0 0 0 0 % Q
% Arg: 0 65 8 8 8 0 8 0 8 0 8 15 8 0 0 % R
% Ser: 0 0 58 0 0 0 0 0 0 0 8 8 0 0 15 % S
% Thr: 0 8 8 8 0 0 0 50 0 0 0 0 8 0 15 % T
% Val: 8 0 0 0 65 0 15 8 72 0 0 15 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 65 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _