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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPEPPS All Species: 8.79
Human Site: Y532 Identified Species: 14.87
UniProt: P55786 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55786 NP_006301.3 919 103276 Y532 K F C A G G S Y V G E D C P Q
Chimpanzee Pan troglodytes XP_001173625 915 102923 Y528 K F C A G G S Y V G E D C P Q
Rhesus Macaque Macaca mulatta XP_001082709 805 90718 D493 S L L P G I R D L S L P P V D
Dog Lupus familis XP_537659 837 94265 V497 N V K P D Q W V K L N L G T V
Cat Felis silvestris
Mouse Mus musculus Q11011 920 103333 Y533 K F C A S G P Y G G E D C P Q
Rat Rattus norvegicus Q9JJ22 930 106401 L521 T L Q K G F P L I T I T V R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001234986 855 96195 K509 T L V L K D V K P D Q W V K L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001157499 872 98035 D506 I S I C T S E D P S C T K T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728614 1075 122740 S695 C K F T A D G S Q A D E N C L
Honey Bee Apis mellifera XP_394245 867 98542 I501 S W I I P I S I S T S K N P E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188563 781 87435 G469 K V T R E I Q G D K Q I L N I
Poplar Tree Populus trichocarpa XP_002308539 857 96803 L510 Y D A H K S F L L Q T K S E T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195035 879 98160 K509 K N F L L E S K S G A Y D L K
Baker's Yeast Sacchar. cerevisiae P32454 935 105566 D576 S T A D V K P D E D K T I Y P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 87.4 90.2 N.A. 97 32.5 N.A. N.A. 84.3 N.A. 80.9 N.A. 47.9 53.5 N.A. 54.3
Protein Similarity: 100 97.7 87.4 90.5 N.A. 98.4 50.9 N.A. N.A. 88.2 N.A. 88 N.A. 61.1 68.5 N.A. 65.5
P-Site Identity: 100 100 6.6 0 N.A. 80 6.6 N.A. N.A. 0 N.A. 0 N.A. 0 13.3 N.A. 6.6
P-Site Similarity: 100 100 13.3 0 N.A. 80 13.3 N.A. N.A. 6.6 N.A. 6.6 N.A. 13.3 26.6 N.A. 13.3
Percent
Protein Identity: 42.7 N.A. N.A. 42.9 35.4 N.A.
Protein Similarity: 58.5 N.A. N.A. 58.9 53.9 N.A.
P-Site Identity: 0 N.A. N.A. 20 0 N.A.
P-Site Similarity: 6.6 N.A. N.A. 26.6 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 22 8 0 0 0 0 8 8 0 0 0 0 % A
% Cys: 8 0 22 8 0 0 0 0 0 0 8 0 22 8 0 % C
% Asp: 0 8 0 8 8 15 0 22 8 15 8 22 8 0 8 % D
% Glu: 0 0 0 0 8 8 8 0 8 0 22 8 0 8 8 % E
% Phe: 0 22 15 0 0 8 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 29 22 8 8 8 29 0 0 8 0 8 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 15 8 0 22 0 8 8 0 8 8 8 0 8 % I
% Lys: 36 8 8 8 15 8 0 15 8 8 8 15 8 8 15 % K
% Leu: 0 22 8 15 8 0 0 15 15 8 8 8 8 8 15 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 0 0 0 0 0 8 0 15 8 0 % N
% Pro: 0 0 0 15 8 0 22 0 15 0 0 8 8 29 8 % P
% Gln: 0 0 8 0 0 8 8 0 8 8 15 0 0 0 22 % Q
% Arg: 0 0 0 8 0 0 8 0 0 0 0 0 0 8 0 % R
% Ser: 22 8 0 0 8 15 29 8 15 15 8 0 8 0 0 % S
% Thr: 15 8 8 8 8 0 0 0 0 15 8 22 0 15 8 % T
% Val: 0 15 8 0 8 0 8 8 15 0 0 0 15 8 8 % V
% Trp: 0 8 0 0 0 0 8 0 0 0 0 8 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 22 0 0 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _