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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
19.09
Human Site:
S239
Identified Species:
28
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
S239
Y
I
F
L
E
Y
A
S
P
A
H
A
V
D
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
S239
Y
I
F
L
E
Y
A
S
P
A
H
A
V
D
A
Dog
Lupus familis
XP_850719
751
86022
S176
Y
T
F
L
E
Y
A
S
P
A
H
A
L
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
S228
Y
I
F
L
E
Y
A
S
P
A
H
A
V
D
A
Rat
Rattus norvegicus
Q4G061
797
90892
S222
Y
I
F
L
E
Y
A
S
P
A
H
A
V
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
K162
D
E
W
D
I
P
E
K
Q
P
F
K
D
L
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
Q161
E
W
D
V
P
E
K
Q
P
F
K
D
F
G
N
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
G159
K
Q
P
F
K
D
F
G
N
L
R
H
W
M
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
D165
Q
T
F
K
V
Q
S
D
L
Y
N
F
I
N
D
Honey Bee
Apis mellifera
XP_393588
702
81532
P161
E
I
P
D
E
W
E
P
P
K
P
Q
E
F
K
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
L175
F
A
I
S
H
D
K
L
G
V
P
T
V
G
V
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
W165
F
M
N
L
P
D
E
W
T
S
P
E
K
Q
P
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
E161
P
D
E
W
A
P
P
E
I
R
P
Y
V
P
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
Y162
E
P
P
Q
A
R
P
Y
V
P
G
E
N
L
Q
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
T182
F
R
E
P
D
M
P
T
F
V
P
S
S
S
L
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
V179
V
M
F
R
G
E
S
V
G
V
F
W
N
N
E
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
86.6
N.A.
100
100
N.A.
0
N.A.
6.6
0
N.A.
6.6
20
6.6
6.6
P-Site Similarity:
100
N.A.
100
93.3
N.A.
100
100
N.A.
6.6
N.A.
13.3
6.6
N.A.
33.3
26.6
13.3
26.6
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
6.6
N.A.
N.A.
0
0
6.6
P-Site Similarity:
6.6
N.A.
N.A.
0
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
13
0
32
0
0
32
0
32
0
0
32
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
13
7
19
0
7
0
0
0
7
7
32
7
% D
% Glu:
19
7
13
0
38
13
19
7
0
0
0
13
7
0
13
% E
% Phe:
19
0
44
7
0
0
7
0
7
7
13
7
7
7
0
% F
% Gly:
0
0
0
0
7
0
0
7
13
0
7
0
0
13
13
% G
% His:
0
0
0
0
7
0
0
0
0
0
32
7
0
0
0
% H
% Ile:
0
32
7
0
7
0
0
0
7
0
0
0
7
0
0
% I
% Lys:
7
0
0
7
7
0
13
7
0
7
7
7
7
0
7
% K
% Leu:
0
0
0
38
0
0
0
7
7
7
0
0
7
13
7
% L
% Met:
0
13
0
0
0
7
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
7
0
0
0
0
0
7
0
7
0
13
13
7
% N
% Pro:
7
7
19
7
13
13
19
7
44
13
32
0
0
7
7
% P
% Gln:
7
7
0
7
0
7
0
7
7
0
0
7
0
7
7
% Q
% Arg:
0
7
0
7
0
7
0
0
0
7
7
0
0
0
0
% R
% Ser:
0
0
0
7
0
0
13
32
0
7
0
7
7
7
0
% S
% Thr:
0
13
0
0
0
0
0
7
7
0
0
7
0
0
0
% T
% Val:
7
0
0
7
7
0
0
7
7
19
0
0
38
0
7
% V
% Trp:
0
7
7
7
0
7
0
7
0
0
0
7
7
0
0
% W
% Tyr:
32
0
0
0
0
32
0
7
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _