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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3B All Species: 17.88
Human Site: S392 Identified Species: 26.22
UniProt: P55884 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55884 NP_001032360.1 814 92482 S392 E R Y L V T F S P L M D T Q D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086876 814 92439 S392 E R Y L V T F S P L M D T Q D
Dog Lupus familis XP_850719 751 86022 S329 E R Y L V T F S P L M G T Q D
Cat Felis silvestris
Mouse Mus musculus Q8JZQ9 803 91352 S381 E R Y L V T F S P L M D T Q D
Rat Rattus norvegicus Q4G061 797 90892 S375 E R Y L V T F S P L M D T Q D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513573 692 80444 K308 S A H W P I F K W S H D G K F
Chicken Gallus gallus
Frog Xenopus laevis Q569Z1 688 80237 K306 S A H W P I F K W S H D G K F
Zebra Danio Brachydanio rerio XP_001335480 681 79630 D302 P I F K W S P D G K F F A R M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q0E940 690 80423 A311 S H D D K F V A R M G E N S I
Honey Bee Apis mellifera XP_393588 702 81532 G304 K R A F F A D G S S V W P I F
Nematode Worm Caenorhab. elegans Q9XWI6 725 83129 K328 L K A P E K D K L E R E Q K I
Sea Urchin Strong. purpuratus XP_001190551 703 81690 A309 R G F S C D N A S N W P V F K
Poplar Tree Populus trichocarpa XP_002308719 719 82814 A304 M R D F K G S A D E F S I G G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5Z1 712 81857 G307 S A D E F S I G G P G G V A G
Baker's Yeast Sacchar. cerevisiae P06103 763 88111 F326 S G L L M A T F P V I K S P Y
Red Bread Mold Neurospora crassa Q7S464 747 85548 N331 D K Y V A R L N P G Q S I S V
Conservation
Percent
Protein Identity: 100 N.A. 98.5 88.3 N.A. 90.4 89.9 N.A. 80.5 N.A. 75.9 73 N.A. 44.9 50.4 24.6 55.4
Protein Similarity: 100 N.A. 98.8 90.5 N.A. 93.2 93.1 N.A. 82.9 N.A. 81.4 80.2 N.A. 60.4 66.3 42.2 70.1
P-Site Identity: 100 N.A. 100 93.3 N.A. 100 100 N.A. 13.3 N.A. 13.3 0 N.A. 0 6.6 0 0
P-Site Similarity: 100 N.A. 100 93.3 N.A. 100 100 N.A. 26.6 N.A. 26.6 20 N.A. 20 20 20 13.3
Percent
Protein Identity: 37.9 N.A. N.A. 35.8 21.2 27.8
Protein Similarity: 57.6 N.A. N.A. 56.8 42.1 48
P-Site Identity: 6.6 N.A. N.A. 0 13.3 13.3
P-Site Similarity: 13.3 N.A. N.A. 6.6 40 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 13 0 7 13 0 19 0 0 0 0 7 7 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 19 7 0 7 13 7 7 0 0 38 0 0 32 % D
% Glu: 32 0 0 7 7 0 0 0 0 13 0 13 0 0 0 % E
% Phe: 0 0 13 13 13 7 44 7 0 0 13 7 0 7 19 % F
% Gly: 0 13 0 0 0 7 0 13 13 7 13 13 13 7 13 % G
% His: 0 7 13 0 0 0 0 0 0 0 13 0 0 0 0 % H
% Ile: 0 7 0 0 0 13 7 0 0 0 7 0 13 7 13 % I
% Lys: 7 13 0 7 13 7 0 19 0 7 0 7 0 19 7 % K
% Leu: 7 0 7 38 0 0 7 0 7 32 0 0 0 0 0 % L
% Met: 7 0 0 0 7 0 0 0 0 7 32 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 7 7 0 7 0 0 7 0 0 % N
% Pro: 7 0 0 7 13 0 7 0 44 7 0 7 7 7 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 7 0 7 32 0 % Q
% Arg: 7 44 0 0 0 7 0 0 7 0 7 0 0 7 0 % R
% Ser: 32 0 0 7 0 13 7 32 13 19 0 13 7 13 0 % S
% Thr: 0 0 0 0 0 32 7 0 0 0 0 0 32 0 0 % T
% Val: 0 0 0 7 32 0 7 0 0 7 7 0 13 0 7 % V
% Trp: 0 0 0 13 7 0 0 0 13 0 7 7 0 0 0 % W
% Tyr: 0 0 38 0 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _