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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
20
Human Site:
S473
Identified Species:
29.33
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
S473
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
S473
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Dog
Lupus familis
XP_850719
751
86022
S410
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
S462
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Rat
Rattus norvegicus
Q4G061
797
90892
S456
G
I
K
D
F
S
W
S
P
G
G
N
I
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
N389
I
R
V
R
N
L
F
N
V
V
D
C
K
L
H
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
N387
I
R
V
R
N
L
F
N
V
V
D
C
K
L
H
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
C383
N
L
F
N
V
V
D
C
K
L
H
W
Q
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
Q392
A
D
C
K
L
H
W
Q
K
S
G
D
Y
L
C
Honey Bee
Apis mellifera
XP_393588
702
81532
E385
L
E
I
P
N
R
N
E
I
R
N
K
N
L
F
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
M409
H
N
V
A
D
A
Q
M
F
W
Q
K
S
G
K
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
L390
A
I
P
S
R
K
E
L
R
V
K
N
L
F
S
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
G385
F
V
P
E
L
G
G
G
N
Q
P
A
R
V
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
V388
G
G
N
Q
P
A
K
V
A
L
V
Q
I
P
S
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
T407
S
V
L
L
A
Y
W
T
P
E
T
N
N
S
A
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
V412
R
S
L
N
L
F
S
V
S
D
A
K
L
H
W
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
N.A.
0
0
N.A.
13.3
0
0
13.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
20
N.A.
20
13.3
N.A.
26.6
6.6
6.6
26.6
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
0
N.A.
N.A.
13.3
26.6
0
P-Site Similarity:
26.6
N.A.
N.A.
26.6
40
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
7
7
13
0
0
7
0
7
7
0
0
38
% A
% Cys:
0
0
7
0
0
0
0
7
0
0
0
13
0
0
7
% C
% Asp:
0
7
0
32
7
0
7
0
0
7
13
7
0
0
0
% D
% Glu:
0
7
0
7
0
0
7
7
0
7
0
0
0
0
0
% E
% Phe:
7
0
7
0
32
7
13
0
7
0
0
0
0
7
7
% F
% Gly:
38
7
0
0
0
7
7
7
0
32
38
0
0
7
0
% G
% His:
7
0
0
0
0
7
0
0
0
0
7
0
0
7
13
% H
% Ile:
13
38
7
0
0
0
0
0
7
0
0
0
38
32
0
% I
% Lys:
0
0
32
7
0
7
7
0
13
0
7
19
13
7
7
% K
% Leu:
7
7
13
7
19
13
0
7
0
13
0
0
13
25
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
7
7
7
13
19
0
7
13
7
0
7
44
13
0
7
% N
% Pro:
0
0
13
7
7
0
0
0
38
0
7
0
0
7
0
% P
% Gln:
0
0
0
7
0
0
7
7
0
7
7
7
7
0
0
% Q
% Arg:
7
13
0
13
7
7
0
0
7
7
0
0
7
0
0
% R
% Ser:
7
7
0
7
0
32
7
32
7
7
0
0
7
7
19
% S
% Thr:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% T
% Val:
0
13
19
0
7
7
0
13
13
19
7
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
44
0
0
7
0
7
0
0
7
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _