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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3B All Species: 23.94
Human Site: T336 Identified Species: 35.11
UniProt: P55884 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55884 NP_001032360.1 814 92482 T336 I E E R A R W T E T Y V R W S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086876 814 92439 T336 I E E R A R W T E T Y V R W S
Dog Lupus familis XP_850719 751 86022 T273 I E E R A R W T E T Y V R W S
Cat Felis silvestris
Mouse Mus musculus Q8JZQ9 803 91352 T325 I E E R A R W T E T Y V R W S
Rat Rattus norvegicus Q4G061 797 90892 T319 I E E R A R W T E T Y V R W S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513573 692 80444 I257 S H Q G V Q L I D F S P C E R
Chicken Gallus gallus
Frog Xenopus laevis Q569Z1 688 80237 I255 S H Q G V Q L I D F S P C E R
Zebra Danio Brachydanio rerio XP_001335480 681 79630 C252 Q L I D F S P C E R Y V V T F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q0E940 690 80423 S258 G T Q F V E F S P C E N Y L V
Honey Bee Apis mellifera XP_393588 702 81532 S254 F L Q Q A R F S Q K G V E C I
Nematode Worm Caenorhab. elegans Q9XWI6 725 83129 G271 P E E S N S W G D C E K D S L
Sea Urchin Strong. purpuratus XP_001190551 703 81690 A258 F Q Q I R R F A H P G V Q L I
Poplar Tree Populus trichocarpa XP_002308719 719 82814 Q254 L M R Y A H P Q V K F I D F S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C5Z1 712 81857 F257 S M V K L V D F S P G E K Y L
Baker's Yeast Sacchar. cerevisiae P06103 763 88111 S275 Y H P D V R N S S V S P N E K
Red Bread Mold Neurospora crassa Q7S464 747 85548 Y279 V E D D G K N Y V I W D I E T
Conservation
Percent
Protein Identity: 100 N.A. 98.5 88.3 N.A. 90.4 89.9 N.A. 80.5 N.A. 75.9 73 N.A. 44.9 50.4 24.6 55.4
Protein Similarity: 100 N.A. 98.8 90.5 N.A. 93.2 93.1 N.A. 82.9 N.A. 81.4 80.2 N.A. 60.4 66.3 42.2 70.1
P-Site Identity: 100 N.A. 100 100 N.A. 100 100 N.A. 0 N.A. 0 20 N.A. 0 20 20 13.3
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 20 N.A. 20 20 N.A. 20 53.3 26.6 40
Percent
Protein Identity: 37.9 N.A. N.A. 35.8 21.2 27.8
Protein Similarity: 57.6 N.A. N.A. 56.8 42.1 48
P-Site Identity: 13.3 N.A. N.A. 0 6.6 6.6
P-Site Similarity: 40 N.A. N.A. 20 13.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 44 0 0 7 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 13 0 0 13 7 0 % C
% Asp: 0 0 7 19 0 0 7 0 19 0 0 7 13 0 0 % D
% Glu: 0 44 38 0 0 7 0 0 38 0 13 7 7 25 0 % E
% Phe: 13 0 0 7 7 0 19 7 0 13 7 0 0 7 7 % F
% Gly: 7 0 0 13 7 0 0 7 0 0 19 0 0 0 0 % G
% His: 0 19 0 0 0 7 0 0 7 0 0 0 0 0 0 % H
% Ile: 32 0 7 7 0 0 0 13 0 7 0 7 7 0 13 % I
% Lys: 0 0 0 7 0 7 0 0 0 13 0 7 7 0 7 % K
% Leu: 7 13 0 0 7 0 13 0 0 0 0 0 0 13 13 % L
% Met: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 13 0 0 0 0 7 7 0 0 % N
% Pro: 7 0 7 0 0 0 13 0 7 13 0 19 0 0 0 % P
% Gln: 7 7 32 7 0 13 0 7 7 0 0 0 7 0 0 % Q
% Arg: 0 0 7 32 7 50 0 0 0 7 0 0 32 0 13 % R
% Ser: 19 0 0 7 0 13 0 19 13 0 19 0 0 7 38 % S
% Thr: 0 7 0 0 0 0 0 32 0 32 0 0 0 7 7 % T
% Val: 7 0 7 0 25 7 0 0 13 7 0 50 7 0 7 % V
% Trp: 0 0 0 0 0 0 38 0 0 0 7 0 0 32 0 % W
% Tyr: 7 0 0 7 0 0 0 7 0 0 38 0 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _