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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
23.64
Human Site:
T533
Identified Species:
34.67
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
T533
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
T533
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Dog
Lupus familis
XP_850719
751
86022
T470
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
T522
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Rat
Rattus norvegicus
Q4G061
797
90892
T516
L
C
V
K
V
D
R
T
P
K
G
T
Q
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
P433
R
M
R
E
K
Q
V
P
V
D
V
V
E
M
K
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
V432
M
R
E
K
Q
V
P
V
D
V
V
E
M
K
D
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
V427
K
Q
V
P
V
D
V
V
E
M
K
D
S
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
I436
F
H
M
R
E
K
E
I
P
V
D
S
V
E
I
Honey Bee
Apis mellifera
XP_393588
702
81532
M429
T
E
Q
K
Y
T
G
M
S
Y
N
F
E
I
F
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
K453
V
D
I
F
E
I
D
K
K
D
V
S
L
M
N
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
R434
F
T
N
F
E
I
F
R
M
Q
E
K
Q
I
P
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
Y431
L
A
V
K
V
D
R
Y
T
K
T
K
K
S
T
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
S437
K
T
K
K
S
T
Y
S
G
F
E
L
F
R
I
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
H457
L
C
F
N
V
E
R
H
T
K
S
G
K
T
Q
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
T461
V
P
V
E
V
V
D
T
I
K
D
T
V
I
N
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
0
N.A.
6.6
20
N.A.
6.6
6.6
0
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
13.3
N.A.
13.3
26.6
N.A.
33.3
13.3
20
13.3
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
46.6
N.A.
N.A.
6.6
33.3
33.3
P-Site Similarity:
53.3
N.A.
N.A.
20
46.6
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
38
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
44
13
0
7
13
13
7
0
0
7
% D
% Glu:
0
7
7
13
19
7
7
0
7
0
13
7
13
7
0
% E
% Phe:
13
0
7
13
0
0
7
0
0
7
0
7
7
0
7
% F
% Gly:
0
0
0
0
0
0
7
0
7
0
32
7
0
32
0
% G
% His:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
13
0
7
7
0
0
0
0
25
19
% I
% Lys:
13
0
7
57
7
7
0
7
7
50
7
13
13
7
7
% K
% Leu:
44
0
0
0
0
0
0
0
0
0
0
7
7
0
0
% L
% Met:
7
7
7
0
0
0
0
7
7
7
0
0
7
13
0
% M
% Asn:
0
0
7
7
0
0
0
0
0
0
7
0
0
0
13
% N
% Pro:
0
7
0
7
0
0
7
7
38
0
0
0
0
0
7
% P
% Gln:
0
7
7
0
7
7
0
0
0
7
0
0
38
0
7
% Q
% Arg:
7
7
7
7
0
0
44
7
0
0
0
0
0
7
0
% R
% Ser:
0
0
0
0
7
0
0
7
7
0
7
13
7
7
0
% S
% Thr:
7
13
0
0
0
13
0
38
13
0
7
38
0
7
7
% T
% Val:
13
0
50
0
57
13
13
13
7
13
19
7
13
0
32
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
7
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _