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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
24.85
Human Site:
T752
Identified Species:
36.44
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
T752
E
L
V
E
R
R
R
T
M
M
E
D
F
R
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
T752
E
L
V
E
R
R
R
T
M
M
E
D
F
R
K
Dog
Lupus familis
XP_850719
751
86022
T689
E
L
V
E
R
R
R
T
M
M
E
D
F
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
T741
E
L
V
E
R
R
R
T
M
M
E
D
F
R
Q
Rat
Rattus norvegicus
Q4G061
797
90892
T735
E
L
V
E
R
R
R
T
M
M
E
D
F
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
T630
E
L
V
E
R
R
R
T
M
M
E
D
F
R
K
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
A628
E
L
I
E
R
R
R
A
M
M
E
E
Y
K
T
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
E623
D
K
R
R
T
M
M
E
E
Y
R
K
H
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
S632
K
E
L
L
E
K
R
S
Q
L
R
E
T
F
M
Honey Bee
Apis mellifera
XP_393588
702
81532
A641
E
L
I
E
K
R
C
A
A
M
K
A
F
E
E
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
K659
E
V
V
E
K
R
R
K
I
M
A
A
F
D
I
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
Q640
E
L
I
E
R
R
Q
Q
Q
M
N
D
F
K
E
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
M656
Q
D
R
E
K
R
R
M
M
K
D
E
W
Y
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
A652
Q
D
R
E
K
R
K
A
L
K
E
E
W
E
K
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
H705
A
M
R
D
L
I
L
H
Q
R
E
L
L
K
Q
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
R681
A
V
V
E
A
R
R
R
L
L
E
E
W
F
A
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
100
N.A.
60
13.3
N.A.
6.6
40
46.6
53.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
86.6
20
N.A.
46.6
66.6
66.6
80
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
33.3
N.A.
N.A.
26.6
6.6
33.3
P-Site Similarity:
66.6
N.A.
N.A.
66.6
33.3
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
0
0
7
0
0
19
7
0
7
13
0
0
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
7
13
0
7
0
0
0
0
0
0
7
44
0
7
0
% D
% Glu:
63
7
0
82
7
0
0
7
7
0
63
32
0
13
13
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
57
13
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% H
% Ile:
0
0
19
0
0
7
0
0
7
0
0
0
0
0
7
% I
% Lys:
7
7
0
0
25
7
7
7
0
13
7
7
0
19
44
% K
% Leu:
0
57
7
7
7
0
7
0
13
13
0
7
7
0
0
% L
% Met:
0
7
0
0
0
7
7
7
50
63
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
13
0
0
0
0
0
7
7
19
0
0
0
0
0
19
% Q
% Arg:
0
0
25
7
50
82
69
7
0
7
13
0
0
44
0
% R
% Ser:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
38
0
0
0
0
7
0
7
% T
% Val:
0
13
50
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _