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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
19.7
Human Site:
Y222
Identified Species:
28.89
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
Y222
G
K
I
T
N
D
F
Y
P
E
E
D
G
K
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
Y222
G
K
I
T
N
D
F
Y
P
E
E
D
G
K
T
Dog
Lupus familis
XP_850719
751
86022
Y159
G
K
I
T
N
D
F
Y
P
E
E
D
G
K
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
Y211
G
K
I
I
N
D
Y
Y
P
E
E
D
G
K
T
Rat
Rattus norvegicus
Q4G061
797
90892
Y205
G
K
I
I
N
D
Y
Y
P
E
E
D
G
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
T145
T
F
R
V
N
L
F
T
D
F
D
K
Y
M
T
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
D144
F
R
V
N
L
F
T
D
F
D
K
Y
M
V
I
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
S142
T
D
F
D
K
Y
M
S
I
C
D
E
W
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
I148
D
F
Q
K
Y
E
N
I
P
E
K
W
E
P
P
Honey Bee
Apis mellifera
XP_393588
702
81532
N144
K
Q
H
T
F
K
V
N
L
F
T
D
F
K
K
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
W158
D
V
G
D
L
W
W
W
L
Q
N
E
R
C
R
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
A148
L
D
K
Q
H
T
F
A
V
N
L
I
T
D
F
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
I144
H
I
F
A
V
N
M
I
E
D
F
N
R
F
M
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
D145
V
N
M
F
D
D
F
D
R
L
M
N
V
K
E
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
R165
Y
T
M
K
D
V
E
R
Y
N
S
D
D
F
D
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
D162
H
L
R
S
F
M
A
D
P
S
G
R
G
R
D
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
100
N.A.
86.6
86.6
N.A.
20
N.A.
0
0
N.A.
13.3
20
0
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
93.3
N.A.
26.6
N.A.
26.6
20
N.A.
26.6
26.6
26.6
13.3
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
0
N.A.
N.A.
20
6.6
13.3
P-Site Similarity:
20
N.A.
N.A.
40
20
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
7
7
0
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% C
% Asp:
13
13
0
13
13
38
0
19
7
13
13
44
7
7
13
% D
% Glu:
0
0
0
0
0
7
7
0
7
38
32
13
7
7
7
% E
% Phe:
7
13
13
7
13
7
38
0
7
13
7
0
7
13
7
% F
% Gly:
32
0
7
0
0
0
0
0
0
0
7
0
38
0
0
% G
% His:
13
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
32
13
0
0
0
13
7
0
0
7
0
0
7
% I
% Lys:
7
32
7
13
7
7
0
0
0
0
13
7
0
44
7
% K
% Leu:
7
7
0
0
13
7
0
0
13
7
7
0
0
0
0
% L
% Met:
0
0
13
0
0
7
13
0
0
0
7
0
7
7
7
% M
% Asn:
0
7
0
7
38
7
7
7
0
13
7
13
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
44
0
0
0
0
7
7
% P
% Gln:
0
7
7
7
0
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
0
7
13
0
0
0
0
7
7
0
0
7
13
7
7
% R
% Ser:
0
0
0
7
0
0
0
7
0
7
7
0
0
0
0
% S
% Thr:
13
7
0
25
0
7
7
7
0
0
7
0
7
0
38
% T
% Val:
7
7
7
7
7
7
7
0
7
0
0
0
7
7
0
% V
% Trp:
0
0
0
0
0
7
7
7
0
0
0
7
7
0
0
% W
% Tyr:
7
0
0
0
7
7
13
32
7
0
0
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _