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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
17.88
Human Site:
Y237
Identified Species:
26.22
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
Y237
K
G
Y
I
F
L
E
Y
A
S
P
A
H
A
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
Y237
K
G
Y
I
F
L
E
Y
A
S
P
A
H
A
V
Dog
Lupus familis
XP_850719
751
86022
Y174
K
G
Y
T
F
L
E
Y
A
S
P
A
H
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
Y226
K
G
Y
I
F
L
E
Y
A
S
P
A
H
A
V
Rat
Rattus norvegicus
Q4G061
797
90892
Y220
K
G
Y
I
F
L
E
Y
A
S
P
A
H
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
P160
I
S
D
E
W
D
I
P
E
K
Q
P
F
K
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
E159
G
D
E
W
D
V
P
E
K
Q
P
F
K
D
F
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
D157
P
E
K
Q
P
F
K
D
F
G
N
L
R
H
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
Q163
T
V
Q
T
F
K
V
Q
S
D
L
Y
N
F
I
Honey Bee
Apis mellifera
XP_393588
702
81532
W159
F
E
E
I
P
D
E
W
E
P
P
K
P
Q
E
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
D173
D
Q
F
A
I
S
H
D
K
L
G
V
P
T
V
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
D163
D
K
F
M
N
L
P
D
E
W
T
S
P
E
K
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
P159
K
V
P
D
E
W
A
P
P
E
I
R
P
Y
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
R160
E
W
E
P
P
Q
A
R
P
Y
V
P
G
E
N
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
M180
T
E
F
R
E
P
D
M
P
T
F
V
P
S
S
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
E177
Q
F
V
M
F
R
G
E
S
V
G
V
F
W
N
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
86.6
N.A.
100
100
N.A.
0
N.A.
6.6
0
N.A.
6.6
20
6.6
6.6
P-Site Similarity:
100
N.A.
100
93.3
N.A.
100
100
N.A.
6.6
N.A.
13.3
6.6
N.A.
26.6
26.6
13.3
26.6
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
13.3
N.A.
N.A.
0
0
6.6
P-Site Similarity:
13.3
N.A.
N.A.
6.6
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
13
0
32
0
0
32
0
32
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
7
7
7
7
13
7
19
0
7
0
0
0
7
7
% D
% Glu:
7
19
19
7
13
0
38
13
19
7
0
0
0
13
7
% E
% Phe:
7
7
19
0
44
7
0
0
7
0
7
7
13
7
7
% F
% Gly:
7
32
0
0
0
0
7
0
0
7
13
0
7
0
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
32
7
0
% H
% Ile:
7
0
0
32
7
0
7
0
0
0
7
0
0
0
7
% I
% Lys:
38
7
7
0
0
7
7
0
13
7
0
7
7
7
7
% K
% Leu:
0
0
0
0
0
38
0
0
0
7
7
7
0
0
7
% L
% Met:
0
0
0
13
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
0
7
0
7
0
13
% N
% Pro:
7
0
7
7
19
7
13
13
19
7
44
13
32
0
0
% P
% Gln:
7
7
7
7
0
7
0
7
0
7
7
0
0
7
0
% Q
% Arg:
0
0
0
7
0
7
0
7
0
0
0
7
7
0
0
% R
% Ser:
0
7
0
0
0
7
0
0
13
32
0
7
0
7
7
% S
% Thr:
13
0
0
13
0
0
0
0
0
7
7
0
0
7
0
% T
% Val:
0
13
7
0
0
7
7
0
0
7
7
19
0
0
38
% V
% Trp:
0
7
0
7
7
7
0
7
0
7
0
0
0
7
7
% W
% Tyr:
0
0
32
0
0
0
0
32
0
7
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _