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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3B
All Species:
20
Human Site:
Y449
Identified Species:
29.33
UniProt:
P55884
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55884
NP_001032360.1
814
92482
Y449
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001086876
814
92439
Y449
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Dog
Lupus familis
XP_850719
751
86022
Y386
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZQ9
803
91352
Y438
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Rat
Rattus norvegicus
Q4G061
797
90892
Y432
T
L
D
T
L
S
I
Y
E
T
P
S
M
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513573
692
80444
K365
A
F
W
V
P
E
D
K
D
I
P
A
R
V
T
Chicken
Gallus gallus
Frog
Xenopus laevis
Q569Z1
688
80237
K363
A
F
W
V
P
E
D
K
D
I
P
A
R
V
T
Zebra Danio
Brachydanio rerio
XP_001335480
681
79630
A359
P
E
D
K
D
I
P
A
R
V
T
L
M
Q
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q0E940
690
80423
M368
I
P
A
R
V
T
L
M
E
I
P
K
K
R
E
Honey Bee
Apis mellifera
XP_393588
702
81532
L361
W
S
P
T
D
N
V
L
A
Y
W
V
P
E
D
Nematode Worm
Caenorhab. elegans
Q9XWI6
725
83129
F385
T
D
A
V
P
A
E
F
G
L
L
Q
V
P
S
Sea Urchin
Strong. purpuratus
XP_001190551
703
81690
S366
S
P
A
S
N
I
M
S
Y
W
T
P
E
E
K
Poplar Tree
Populus trichocarpa
XP_002308719
719
82814
E361
D
K
K
S
L
K
A
E
N
V
M
D
F
I
W
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9C5Z1
712
81857
C364
V
D
N
V
V
D
I
C
W
S
P
T
D
S
I
Baker's Yeast
Sacchar. cerevisiae
P06103
763
88111
F383
S
G
I
R
D
F
S
F
A
P
E
G
V
K
L
Red Bread Mold
Neurospora crassa
Q7S464
747
85548
S388
F
W
T
P
E
I
G
S
N
P
A
R
V
G
L
Conservation
Percent
Protein Identity:
100
N.A.
98.5
88.3
N.A.
90.4
89.9
N.A.
80.5
N.A.
75.9
73
N.A.
44.9
50.4
24.6
55.4
Protein Similarity:
100
N.A.
98.8
90.5
N.A.
93.2
93.1
N.A.
82.9
N.A.
81.4
80.2
N.A.
60.4
66.3
42.2
70.1
P-Site Identity:
100
N.A.
100
100
N.A.
100
100
N.A.
6.6
N.A.
6.6
13.3
N.A.
13.3
6.6
6.6
0
P-Site Similarity:
100
N.A.
100
100
N.A.
100
100
N.A.
20
N.A.
20
13.3
N.A.
33.3
20
26.6
20
Percent
Protein Identity:
37.9
N.A.
N.A.
35.8
21.2
27.8
Protein Similarity:
57.6
N.A.
N.A.
56.8
42.1
48
P-Site Identity:
6.6
N.A.
N.A.
13.3
6.6
13.3
P-Site Similarity:
13.3
N.A.
N.A.
46.6
26.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
19
0
0
7
7
7
13
0
7
13
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
7
13
38
0
19
7
13
0
13
0
0
7
7
0
7
% D
% Glu:
0
7
0
0
7
13
7
7
38
0
7
0
7
13
7
% E
% Phe:
7
13
0
0
0
7
0
13
0
0
0
0
7
0
7
% F
% Gly:
0
7
0
0
0
0
7
0
7
0
0
7
0
38
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
0
0
19
38
0
0
19
0
0
0
7
7
% I
% Lys:
0
7
7
7
0
7
0
13
0
0
0
7
7
7
7
% K
% Leu:
0
32
0
0
38
0
7
7
0
7
7
7
0
0
44
% L
% Met:
0
0
0
0
0
0
7
7
0
0
7
0
38
0
0
% M
% Asn:
0
0
7
0
7
7
0
0
13
0
0
0
0
0
0
% N
% Pro:
7
13
7
7
19
0
7
0
0
13
57
7
7
7
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% Q
% Arg:
0
0
0
13
0
0
0
0
7
0
0
7
13
7
0
% R
% Ser:
13
7
0
13
0
32
7
13
0
7
0
32
0
7
7
% S
% Thr:
38
0
7
38
0
7
0
0
0
32
13
7
0
0
13
% T
% Val:
7
0
0
25
13
0
7
0
0
13
0
7
19
13
0
% V
% Trp:
7
7
13
0
0
0
0
0
7
7
7
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
32
7
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _