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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSW
All Species:
15.15
Human Site:
S121
Identified Species:
41.67
UniProt:
P56202
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56202
NP_001326.2
376
42120
S121
S
M
G
R
E
I
R
S
E
E
P
E
E
S
V
Chimpanzee
Pan troglodytes
XP_001170363
376
42176
S121
S
M
G
R
E
I
R
S
E
E
P
E
E
S
V
Rhesus Macaque
Macaca mulatta
XP_001112560
375
41849
S121
G
M
G
R
E
I
G
S
E
E
P
Q
E
S
V
Dog
Lupus familis
XP_540846
374
41757
S121
S
V
G
R
K
V
E
S
E
E
W
G
E
P
V
Cat
Felis silvestris
Mouse
Mus musculus
P56203
371
42101
S119
N
M
T
K
K
V
E
S
N
T
W
G
E
S
V
Rat
Rattus norvegicus
P00786
333
37086
S84
L
N
Q
F
S
D
M
S
F
A
E
I
K
H
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002305451
368
40264
L131
D
A
N
E
A
P
I
L
P
T
S
D
L
P
E
Maize
Zea mays
Q10716
371
40329
A126
L
R
E
L
G
E
S
A
H
E
A
P
V
L
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43296
368
40400
I129
K
D
A
N
K
A
P
I
L
P
T
E
N
L
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
94.4
73.1
N.A.
68
28.9
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.9
96.2
81.1
N.A.
78.7
46.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
53.3
N.A.
33.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
73.3
N.A.
60
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
36.9
34.5
N.A.
32.9
N.A.
N.A.
Protein Similarity:
53.9
51.6
N.A.
52.6
N.A.
N.A.
P-Site Identity:
0
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
6.6
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
0
12
12
0
12
0
12
12
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
12
0
0
0
12
0
0
0
0
0
12
0
0
0
% D
% Glu:
0
0
12
12
34
12
23
0
45
56
12
34
56
0
12
% E
% Phe:
0
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% F
% Gly:
12
0
45
0
12
0
12
0
0
0
0
23
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
12
0
0
0
0
12
0
% H
% Ile:
0
0
0
0
0
34
12
12
0
0
0
12
0
0
0
% I
% Lys:
12
0
0
12
34
0
0
0
0
0
0
0
12
0
12
% K
% Leu:
23
0
0
12
0
0
0
12
12
0
0
0
12
23
0
% L
% Met:
0
45
0
0
0
0
12
0
0
0
0
0
0
0
0
% M
% Asn:
12
12
12
12
0
0
0
0
12
0
0
0
12
0
0
% N
% Pro:
0
0
0
0
0
12
12
0
12
12
34
12
0
23
23
% P
% Gln:
0
0
12
0
0
0
0
0
0
0
0
12
0
0
0
% Q
% Arg:
0
12
0
45
0
0
23
0
0
0
0
0
0
0
0
% R
% Ser:
34
0
0
0
12
0
12
67
0
0
12
0
0
45
0
% S
% Thr:
0
0
12
0
0
0
0
0
0
23
12
0
0
0
0
% T
% Val:
0
12
0
0
0
23
0
0
0
0
0
0
12
0
56
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
23
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _