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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLE2 All Species: 31.21
Human Site: S154 Identified Species: 45.78
UniProt: P56282 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P56282 NP_002683.2 527 59537 S154 F T P P V I G S H P D E S G S
Chimpanzee Pan troglodytes XP_509931 527 59578 S154 F T P P V I G S H P D E S G S
Rhesus Macaque Macaca mulatta XP_001095940 525 59213 S157 F T P P V I G S H P D E S G S
Dog Lupus familis XP_851216 527 59504 S154 F T P P V I G S H P D E T G S
Cat Felis silvestris
Mouse Mus musculus O54956 527 59368 S154 F T P P V I G S H L E E S G S
Rat Rattus norvegicus XP_216727 527 59187 S154 F T P P V I G S H P D E S G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515002 535 60459 A162 F T P P V I G A H P D E S R S
Chicken Gallus gallus Q5ZKQ6 527 59609 I154 F T P A A V V I H P D D N R S
Frog Xenopus laevis NP_001083783 527 59670 S154 F T P P V I G S H P D E S R S
Zebra Danio Brachydanio rerio NP_775353 527 59243 S154 F T P P V I G S A Q D E G R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647995 525 58740 G153 A P A V I Q D G V G A E A Q A
Honey Bee Apis mellifera XP_001120791 454 52119 I106 E A Q Y K S T I F K D R F E L
Nematode Worm Caenorhab. elegans Q19196 534 60979 G159 F T T C E I L G S S T K H L Q
Sea Urchin Strong. purpuratus XP_796825 501 56117 G145 K P V E F L L G S T A K L G E
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147081 533 59891 P156 R D K Y F S K P A F D T V A T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24482 689 78322 S255 V S L Q N E L S N T N R Q Q Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 92.4 93.5 N.A. 90.1 90.8 N.A. 86.1 82.1 81 73.2 N.A. 42.1 39.2 30.8 57.6
Protein Similarity: 100 99.2 94.3 97.1 N.A. 94.8 95.2 N.A. 90.8 91.4 91 88 N.A. 59.7 58 51.1 75.7
P-Site Identity: 100 100 100 93.3 N.A. 86.6 100 N.A. 86.6 46.6 93.3 66.6 N.A. 6.6 6.6 20 6.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. 93.3 66.6 93.3 73.3 N.A. 26.6 6.6 26.6 20
Percent
Protein Identity: N.A. 36.2 N.A. N.A. 24.3 N.A.
Protein Similarity: N.A. 56.2 N.A. N.A. 42.9 N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 7 7 0 0 7 13 0 13 0 7 7 7 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 7 0 0 0 69 7 0 0 0 % D
% Glu: 7 0 0 7 7 7 0 0 0 0 7 63 0 7 7 % E
% Phe: 69 0 0 0 13 0 0 0 7 7 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 57 19 0 7 0 0 7 44 0 % G
% His: 0 0 0 0 0 0 0 0 57 0 0 0 7 0 0 % H
% Ile: 0 0 0 0 7 63 0 13 0 0 0 0 0 0 0 % I
% Lys: 7 0 7 0 7 0 7 0 0 7 0 13 0 0 0 % K
% Leu: 0 0 7 0 0 7 19 0 0 7 0 0 7 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 0 7 0 7 0 7 0 7 % N
% Pro: 0 13 63 57 0 0 0 7 0 50 0 0 0 0 0 % P
% Gln: 0 0 7 7 0 7 0 0 0 7 0 0 7 13 13 % Q
% Arg: 7 0 0 0 0 0 0 0 0 0 0 13 0 25 0 % R
% Ser: 0 7 0 0 0 13 0 57 13 7 0 0 44 0 57 % S
% Thr: 0 69 7 0 0 0 7 0 0 13 7 7 7 0 7 % T
% Val: 7 0 7 7 57 7 7 0 7 0 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _