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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLE2 All Species: 31.82
Human Site: Y467 Identified Species: 46.67
UniProt: P56282 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P56282 NP_002683.2 527 59537 Y467 P V Y W A Y D Y A L R V Y P V
Chimpanzee Pan troglodytes XP_509931 527 59578 Y467 P V Y W A Y D Y A L R V Y P V
Rhesus Macaque Macaca mulatta XP_001095940 525 59213 W466 L Y V C P V Y W A Y D Y A L R
Dog Lupus familis XP_851216 527 59504 Y467 P V Y W A Y D Y A L R V Y P V
Cat Felis silvestris
Mouse Mus musculus O54956 527 59368 Y467 P V H W A Y D Y T L R V Y P V
Rat Rattus norvegicus XP_216727 527 59187 Y467 P V Y W A Y D Y T L R V Y P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515002 535 60459 Y475 P V Y W A Y D Y T M R V Y P V
Chicken Gallus gallus Q5ZKQ6 527 59609 Y467 P V Y W A Y D Y A L R V Y P V
Frog Xenopus laevis NP_001083783 527 59670 Y467 P V Y W A Y D Y A L R L Y P L
Zebra Danio Brachydanio rerio NP_775353 527 59243 H467 P V F W A Y D H T L R L Y P V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_647995 525 58740 P463 P V H W D Y D P A L W L Y P L
Honey Bee Apis mellifera XP_001120791 454 52119 Y395 Y N H S L Q I Y P T P D L I V
Nematode Worm Caenorhab. elegans Q19196 534 60979 H454 P V L P D F S H S L S L H P L
Sea Urchin Strong. purpuratus XP_796825 501 56117 N439 P V Y W A Y D N A L R I Y P L
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147081 533 59891 D474 Q P I I W N Y D H C L R L Y P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24482 689 78322 H628 P I S W D L D H T L T L C P I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 92.4 93.5 N.A. 90.1 90.8 N.A. 86.1 82.1 81 73.2 N.A. 42.1 39.2 30.8 57.6
Protein Similarity: 100 99.2 94.3 97.1 N.A. 94.8 95.2 N.A. 90.8 91.4 91 88 N.A. 59.7 58 51.1 75.7
P-Site Identity: 100 100 6.6 100 N.A. 86.6 93.3 N.A. 86.6 100 86.6 73.3 N.A. 60 13.3 26.6 80
P-Site Similarity: 100 100 13.3 100 N.A. 93.3 93.3 N.A. 93.3 100 100 93.3 N.A. 80 20 66.6 93.3
Percent
Protein Identity: N.A. 36.2 N.A. N.A. 24.3 N.A.
Protein Similarity: N.A. 56.2 N.A. N.A. 42.9 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. 0 N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 63 0 0 0 50 0 0 0 7 0 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 7 0 0 7 0 0 % C
% Asp: 0 0 0 0 19 0 75 7 0 0 7 7 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 7 0 0 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 19 0 0 0 0 19 7 0 0 0 7 0 0 % H
% Ile: 0 7 7 7 0 0 7 0 0 0 0 7 0 7 7 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 0 7 0 7 7 0 0 0 75 7 32 13 7 25 % L
% Met: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 7 0 7 0 0 0 0 0 0 0 % N
% Pro: 82 7 0 7 7 0 0 7 7 0 7 0 0 82 7 % P
% Gln: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 63 7 0 0 7 % R
% Ser: 0 0 7 7 0 0 7 0 7 0 7 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 32 7 7 0 0 0 0 % T
% Val: 0 75 7 0 0 7 0 0 0 0 0 44 0 0 57 % V
% Trp: 0 0 0 75 7 0 0 7 0 0 7 0 0 0 0 % W
% Tyr: 7 7 50 0 0 69 13 57 0 7 0 7 69 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _