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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN8
All Species:
22.84
Human Site:
S220
Identified Species:
62.82
UniProt:
P56748
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56748
NP_955360.1
225
24845
S220
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
_
Chimpanzee
Pan troglodytes
XP_531532
225
24837
S220
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
_
Rhesus Macaque
Macaca mulatta
XP_001100214
225
24981
S220
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
_
Dog
Lupus familis
XP_851577
225
24814
S220
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z260
225
24929
S220
K
R
S
P
S
I
Y
S
K
S
Q
Y
V
_
_
Rat
Rattus norvegicus
Q9JKD6
218
23054
D213
T
T
A
N
G
D
Y
D
K
K
N
Y
V
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425544
224
24558
S219
G
A
T
E
S
A
Y
S
K
S
Q
Y
V
_
_
Frog
Xenopus laevis
NP_001087400
213
22866
D208
R
S
T
N
P
G
Y
D
K
K
D
Y
V
_
_
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
S198
R
A
Y
S
V
K
Y
S
A
P
R
S
A
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.7
84.4
N.A.
82.6
38.6
N.A.
N.A.
65.7
48.8
42.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.6
92.8
N.A.
93.7
61.3
N.A.
N.A.
78.2
66.2
64.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
76.9
23
N.A.
N.A.
53.8
23
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
38.4
N.A.
N.A.
69.2
46.1
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
23
12
0
0
12
0
0
12
0
0
0
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
12
0
23
0
0
12
0
0
0
0
% D
% Glu:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
0
0
0
12
12
0
0
0
0
0
0
0
0
12
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% I
% Lys:
56
45
0
0
0
12
0
0
45
23
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
23
0
0
0
0
0
0
12
0
0
0
0
% N
% Pro:
0
0
0
56
12
0
0
0
0
12
0
0
0
12
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
67
0
0
0
0
% Q
% Arg:
23
12
0
0
0
0
0
0
45
0
12
0
0
0
0
% R
% Ser:
0
12
56
12
67
0
0
78
0
67
0
12
0
0
0
% S
% Thr:
12
12
23
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
12
45
0
0
0
0
0
0
89
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
100
0
0
0
0
89
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
89
89
% _