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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN8
All Species:
25.22
Human Site:
Y219
Identified Species:
69.35
UniProt:
P56748
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56748
NP_955360.1
225
24845
Y219
G
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
Chimpanzee
Pan troglodytes
XP_531532
225
24837
Y219
G
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
Rhesus Macaque
Macaca mulatta
XP_001100214
225
24981
Y219
E
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
Dog
Lupus familis
XP_851577
225
24814
Y219
E
K
K
S
P
S
V
Y
S
R
S
Q
Y
V
_
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z260
225
24929
Y219
E
K
R
S
P
S
I
Y
S
K
S
Q
Y
V
_
Rat
Rattus norvegicus
Q9JKD6
218
23054
Y212
R
T
T
A
N
G
D
Y
D
K
K
N
Y
V
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_425544
224
24558
Y218
H
G
A
T
E
S
A
Y
S
K
S
Q
Y
V
_
Frog
Xenopus laevis
NP_001087400
213
22866
Y207
A
R
S
T
N
P
G
Y
D
K
K
D
Y
V
_
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
Y197
G
R
A
Y
S
V
K
Y
S
A
P
R
S
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.7
84.4
N.A.
82.6
38.6
N.A.
N.A.
65.7
48.8
42.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.6
92.8
N.A.
93.7
61.3
N.A.
N.A.
78.2
66.2
64.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
92.8
92.8
N.A.
71.4
21.4
N.A.
N.A.
50
21.4
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
92.8
92.8
N.A.
92.8
35.7
N.A.
N.A.
64.2
42.8
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
23
12
0
0
12
0
0
12
0
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
12
0
23
0
0
12
0
0
0
% D
% Glu:
34
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
34
12
0
0
0
12
12
0
0
0
0
0
0
0
0
% G
% His:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% I
% Lys:
0
56
45
0
0
0
12
0
0
45
23
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
23
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
0
0
0
0
56
12
0
0
0
0
12
0
0
0
12
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
67
0
0
0
% Q
% Arg:
12
23
12
0
0
0
0
0
0
45
0
12
0
0
0
% R
% Ser:
0
0
12
56
12
67
0
0
78
0
67
0
12
0
0
% S
% Thr:
0
12
12
23
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
12
45
0
0
0
0
0
0
89
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
12
0
0
0
100
0
0
0
0
89
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
89
% _