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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BACE1
All Species:
15.45
Human Site:
Y260
Identified Species:
34
UniProt:
P56817
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56817
NP_036236.1
501
55764
Y260
P
I
R
R
E
W
Y
Y
E
V
I
I
V
R
V
Chimpanzee
Pan troglodytes
XP_508778
415
46502
L209
V
D
S
G
T
T
N
L
R
L
P
K
K
V
F
Rhesus Macaque
Macaca mulatta
P11489
388
41678
I182
Y
Y
A
P
F
D
G
I
L
G
L
A
Y
P
S
Dog
Lupus familis
XP_546508
429
48175
L223
V
D
S
G
T
T
N
L
R
L
P
K
K
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P56818
501
55729
Y260
P
I
R
R
E
W
Y
Y
E
V
I
I
V
R
V
Rat
Rattus norvegicus
P56819
501
55788
Y260
P
I
R
R
E
W
Y
Y
E
V
I
I
V
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509790
498
54928
Y257
P
I
R
R
E
W
Y
Y
E
V
I
I
V
R
M
Chicken
Gallus gallus
Q05744
398
43280
F191
D
G
I
L
G
M
A
F
P
R
I
S
V
D
K
Frog
Xenopus laevis
Q805F2
397
42983
G191
G
Y
P
S
I
A
V
G
G
C
T
P
V
F
D
Zebra Danio
Brachydanio rerio
NP_991267
505
55643
Y265
T
P
I
R
R
E
W
Y
Y
E
V
I
I
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001187192
538
59189
P266
H
G
T
M
Q
Y
A
P
L
R
D
E
W
F
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.6
23.1
83.2
N.A.
96.2
96.2
N.A.
89.4
23.9
20.7
74.2
N.A.
N.A.
N.A.
N.A.
42.1
Protein Similarity:
100
82.6
38.5
84.4
N.A.
97.5
97.5
N.A.
92.8
39.7
39.7
83.5
N.A.
N.A.
N.A.
N.A.
57.2
P-Site Identity:
100
0
0
0
N.A.
100
100
N.A.
93.3
13.3
6.6
20
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
6.6
6.6
6.6
N.A.
100
100
N.A.
100
20
6.6
40
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
10
19
0
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
10
19
0
0
0
10
0
0
0
0
10
0
0
10
10
% D
% Glu:
0
0
0
0
37
10
0
0
37
10
0
10
0
0
0
% E
% Phe:
0
0
0
0
10
0
0
10
0
0
0
0
0
19
19
% F
% Gly:
10
19
0
19
10
0
10
10
10
10
0
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
37
19
0
10
0
0
10
0
0
46
46
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
19
19
0
10
% K
% Leu:
0
0
0
10
0
0
0
19
19
19
10
0
0
0
0
% L
% Met:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% N
% Pro:
37
10
10
10
0
0
0
10
10
0
19
10
0
10
0
% P
% Gln:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
37
46
10
0
0
0
19
19
0
0
0
37
10
% R
% Ser:
0
0
19
10
0
0
0
0
0
0
0
10
0
0
10
% S
% Thr:
10
0
10
0
19
19
0
0
0
0
10
0
0
0
0
% T
% Val:
19
0
0
0
0
0
10
0
0
37
10
0
55
28
28
% V
% Trp:
0
0
0
0
0
37
10
0
0
0
0
0
10
0
0
% W
% Tyr:
10
19
0
0
0
10
37
46
10
0
0
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _