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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN18
All Species:
18.48
Human Site:
S228
Identified Species:
45.19
UniProt:
P56856
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56856
NP_001002026.1
261
27856
S228
K
P
G
G
F
K
A
S
T
G
F
G
S
N
T
Chimpanzee
Pan troglodytes
XP_526318
261
27868
S228
K
P
G
G
F
K
A
S
T
G
F
G
S
N
T
Rhesus Macaque
Macaca mulatta
XP_001114724
261
27821
S228
K
P
G
G
F
K
A
S
T
G
F
G
S
N
T
Dog
Lupus familis
XP_534274
261
27890
S228
K
P
G
G
F
K
A
S
T
G
F
G
P
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P56857
264
28103
S231
R
P
G
G
F
K
A
S
T
G
F
G
S
N
T
Rat
Rattus norvegicus
Q5QT56
224
23297
A192
T
C
P
E
P
E
R
A
N
S
I
P
Q
P
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521504
305
34257
S270
A
G
S
I
C
K
M
S
L
Q
P
L
R
L
F
Chicken
Gallus gallus
XP_426691
259
28261
G224
R
T
G
P
Y
K
A
G
S
G
Y
E
P
E
T
Frog
Xenopus laevis
NP_001083443
260
27985
Y227
V
S
T
K
T
P
G
Y
K
T
S
A
Y
E
D
Zebra Danio
Brachydanio rerio
Q9YH92
215
22846
A183
I
M
G
G
G
M
L
A
S
S
C
S
K
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
93.8
N.A.
87.8
31
N.A.
32.1
74.3
76.6
31.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
99.2
98.4
N.A.
95.8
52.1
N.A.
48.5
86.2
86.9
48.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
93.3
0
N.A.
13.3
33.3
0
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
13.3
N.A.
13.3
60
0
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
60
20
0
0
0
10
0
0
0
% A
% Cys:
0
10
0
0
10
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
0
0
10
0
10
0
0
0
0
0
10
0
20
0
% E
% Phe:
0
0
0
0
50
0
0
0
0
0
50
0
0
0
10
% F
% Gly:
0
10
70
60
10
0
10
10
0
60
0
50
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% I
% Lys:
40
0
0
10
0
70
0
0
10
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
0
0
10
0
10
0
0
10
0
10
0
% L
% Met:
0
10
0
0
0
10
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
40
0
% N
% Pro:
0
50
10
10
10
10
0
0
0
0
10
10
20
10
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
10
% Q
% Arg:
20
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% R
% Ser:
0
10
10
0
0
0
0
60
20
20
10
10
40
10
10
% S
% Thr:
10
10
10
0
10
0
0
0
50
10
0
0
0
0
50
% T
% Val:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
10
0
0
10
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _