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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 25.45
Human Site: S226 Identified Species: 40
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S226 P F S T Q C G S P A Y A A P E
Chimpanzee Pan troglodytes Q68UT7 714 79665 S226 P F S T Q C G S P A Y A A P E
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 P213 L D T F C G S P P Y A A P E L
Dog Lupus familis XP_544857 756 84391 S268 P F S T Q C G S P A Y A A P E
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S226 P F S T Q C G S P A Y A A P E
Rat Rattus norvegicus O08679 722 80853 P213 L D T F C G S P P Y A A P E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 S230 L L N T Q C G S P A Y A A P E
Chicken Gallus gallus Q9IA88 798 88848 P186 L S T W C G S P P Y A A P E V
Frog Xenopus laevis Q5XHI9 691 78470 S219 P F S T Q C G S P A Y A A P E
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 P219 L K T W C G S P P Y A A P E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 P330 L D T F C G S P P Y A A P E L
Sea Urchin Strong. purpuratus XP_794043 962 106011 S228 F A G T L C G S P A Y A A P E
Poplar Tree Populus trichocarpa XP_002306053 515 59069 V64 N M D M E E K V R R E I K I L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 M61 R K I K N M E M E E K V R R E
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 I173 E Y C H R H K I V H R D L K P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 13.3 100 N.A. 100 13.3 N.A. 80 13.3 100 13.3 N.A. N.A. N.A. 13.3 73.3
P-Site Similarity: 100 100 20 100 N.A. 100 20 N.A. 86.6 20 100 20 N.A. N.A. N.A. 20 73.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 0 0 0 0 47 34 80 47 0 0 % A
% Cys: 0 0 7 0 34 47 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 7 0 0 0 0 0 0 0 0 7 0 0 0 % D
% Glu: 7 0 0 0 7 7 7 0 7 7 7 0 0 34 54 % E
% Phe: 7 34 0 20 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 7 0 0 34 47 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 7 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 7 0 0 0 7 0 7 0 % I
% Lys: 0 14 0 7 0 0 14 0 0 0 7 0 7 7 0 % K
% Leu: 40 7 0 0 7 0 0 0 0 0 0 0 7 0 34 % L
% Met: 0 7 0 7 0 7 0 7 0 0 0 0 0 0 0 % M
% Asn: 7 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 34 0 0 0 0 0 0 34 80 0 0 0 34 47 7 % P
% Gln: 0 0 0 0 40 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 0 0 7 0 0 0 7 7 7 0 7 7 0 % R
% Ser: 0 7 34 0 0 0 34 47 0 0 0 0 0 0 0 % S
% Thr: 0 0 34 47 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 7 7 0 0 7 0 0 7 % V
% Trp: 0 0 0 14 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 34 47 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _