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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 13.33
Human Site: S421 Identified Species: 20.95
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S421 P K E S Y E A S L D T W T R D
Chimpanzee Pan troglodytes Q68UT7 714 79665 S421 P K E S Y E A S L D T W T R D
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 V401 A P S P S H K V Q R S V S A N
Dog Lupus familis XP_544857 756 84391 S463 T K E P Y E A S L D T W T R D
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S421 T K E P Y E A S L D T W T R D
Rat Rattus norvegicus O08679 722 80853 Q405 S V S A N P K Q R R S S D Q A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 A425 D P D A G T P A T Q R I E D T
Chicken Gallus gallus Q9IA88 798 88848 T380 E M P Q D S L T S E T L R S S
Frog Xenopus laevis Q5XHI9 691 78470 E412 K M N K N S Y E E R R S K D L
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 P479 P G F P R V A P Q A P F P P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 E522 P A G V I T R E H V T S S S A
Sea Urchin Strong. purpuratus XP_794043 962 106011 E440 E D V D L D D E A D G V T E A
Poplar Tree Populus trichocarpa XP_002306053 515 59069 P249 P G A R D L I P R M L V V D P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 R246 S H L S S E A R D L I P R M L
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 D361 S T M G Y E K D E I Y E S L E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 0 86.6 N.A. 86.6 0 N.A. 0 6.6 0 13.3 N.A. N.A. N.A. 13.3 13.3
P-Site Similarity: 100 100 20 86.6 N.A. 86.6 20 N.A. 20 20 0 20 N.A. N.A. N.A. 20 20
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 6.6 N.A. N.A. 20 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 7 14 0 0 40 7 7 7 0 0 0 7 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 7 7 14 7 7 7 7 34 0 0 7 20 27 % D
% Glu: 14 0 27 0 0 40 0 20 14 7 0 7 7 7 7 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 0 14 7 7 7 0 0 0 0 0 7 0 0 0 0 % G
% His: 0 7 0 0 0 7 0 0 7 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 7 0 0 7 7 7 0 0 0 % I
% Lys: 7 27 0 7 0 0 20 0 0 0 0 0 7 0 0 % K
% Leu: 0 0 7 0 7 7 7 0 27 7 7 7 0 7 20 % L
% Met: 0 14 7 0 0 0 0 0 0 7 0 0 0 7 0 % M
% Asn: 0 0 7 0 14 0 0 0 0 0 0 0 0 0 7 % N
% Pro: 34 14 7 27 0 7 7 14 0 0 7 7 7 7 7 % P
% Gln: 0 0 0 7 0 0 0 7 14 7 0 0 0 7 0 % Q
% Arg: 0 0 0 7 7 0 7 7 14 20 14 0 14 27 0 % R
% Ser: 20 0 14 20 14 14 0 27 7 0 14 20 20 14 7 % S
% Thr: 14 7 0 0 0 14 0 7 7 0 40 0 34 0 7 % T
% Val: 0 7 7 7 0 7 0 7 0 7 0 20 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 27 0 0 0 % W
% Tyr: 0 0 0 0 34 0 7 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _