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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 16.67
Human Site: S463 Identified Species: 26.19
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S463 K L D K N L P S H K Q P S G S
Chimpanzee Pan troglodytes Q68UT7 714 79665 S463 K L D K N L P S H K Q P S G S
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 E444 A E N K R P E E D R E S G R K
Dog Lupus familis XP_544857 756 84391 S505 K L D K N L P S H K Q P S P S
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S463 K L D K N L P S H K Q P S P S
Rat Rattus norvegicus O08679 722 80853 P436 N N A E N K R P E E E T G R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 A463 A I K E D E I A I I L E N Q E
Chicken Gallus gallus Q9IA88 798 88848 G426 P V D P N F N G L F R N R S I
Frog Xenopus laevis Q5XHI9 691 78470 H441 L D K C S P S H R Q N A C L T
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 Y661 T Q Q Q H V L Y Q Q E Q Q I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 K565 A S A A N A Q K H Q Q S S A A
Sea Urchin Strong. purpuratus XP_794043 962 106011 G490 Q I A G K K N G S F H F K M A
Poplar Tree Populus trichocarpa XP_002306053 515 59069 Y278 F Q A R L P R Y L A V P P P D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 H275 Q H R W F Q T H L P R Y L A V
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 S391 M L I K E N K S L I K D M K A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 6.6 93.3 N.A. 93.3 6.6 N.A. 0 13.3 0 0 N.A. N.A. N.A. 26.6 0
P-Site Similarity: 100 100 26.6 93.3 N.A. 93.3 26.6 N.A. 33.3 26.6 20 33.3 N.A. N.A. N.A. 40 20
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 20 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 27 7 0 7 0 7 0 7 0 7 0 14 20 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 7 34 0 7 0 0 0 7 0 0 7 0 0 7 % D
% Glu: 0 7 0 14 7 7 7 7 7 7 20 7 0 0 7 % E
% Phe: 7 0 0 0 7 7 0 0 0 14 0 7 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 14 0 0 0 0 14 14 0 % G
% His: 0 7 0 0 7 0 0 14 34 0 7 0 0 0 0 % H
% Ile: 0 14 7 0 0 0 7 0 7 14 0 0 0 7 7 % I
% Lys: 27 0 14 40 7 14 7 7 0 27 7 0 7 7 14 % K
% Leu: 7 34 0 0 7 27 7 0 27 0 7 0 7 7 7 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 7 7 0 % M
% Asn: 7 7 7 0 47 7 14 0 0 0 7 7 7 0 0 % N
% Pro: 7 0 0 7 0 20 27 7 0 7 0 34 7 20 0 % P
% Gln: 14 14 7 7 0 7 7 0 7 20 34 7 7 7 0 % Q
% Arg: 0 0 7 7 7 0 14 0 7 7 14 0 7 14 0 % R
% Ser: 0 7 0 0 7 0 7 34 7 0 0 14 34 7 27 % S
% Thr: 7 0 0 0 0 0 7 0 0 0 0 7 0 0 7 % T
% Val: 0 7 0 0 0 7 0 0 0 0 7 0 0 0 7 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 14 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _