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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 16.97
Human Site: S490 Identified Species: 26.67
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S490 K D R K A S K S S F P D K D S
Chimpanzee Pan troglodytes Q68UT7 714 79665 S490 K D R K A S K S S F P D K D S
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 T471 P G L E R K K T T P T P S T N
Dog Lupus familis XP_544857 756 84391 S532 K D R K A P K S G F P D K D A
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S490 K D R K A S K S G F P D K D S
Rat Rattus norvegicus O08679 722 80853 T463 P G L D R K K T T P T P S T N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 N490 L E P L L L M N Q K S L G E S
Chicken Gallus gallus Q9IA88 798 88848 L453 E V R Q E K E L E D E I K A Y
Frog Xenopus laevis Q5XHI9 691 78470 R468 R R S S K S E R E S F G G L S
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 L688 E N Q P S S H L T Y Q L Q R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A592 Q N D A A A T A A G G T V V M
Sea Urchin Strong. purpuratus XP_794043 962 106011 S517 S P T N V S S S S K A T E T S
Poplar Tree Populus trichocarpa XP_002306053 515 59069 G305 L Q E V I K M G F D R N Q L I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 V302 N E E I V Q E V V N M G F D R
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 Q418 S Q S P P T F Q Q Q S K S H Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 6.6 80 N.A. 93.3 6.6 N.A. 6.6 13.3 13.3 6.6 N.A. N.A. N.A. 6.6 26.6
P-Site Similarity: 100 100 33.3 86.6 N.A. 93.3 26.6 N.A. 26.6 33.3 26.6 53.3 N.A. N.A. N.A. 40 33.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 34 7 0 7 7 0 7 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 27 7 7 0 0 0 0 0 14 0 27 0 34 0 % D
% Glu: 14 14 14 7 7 0 20 0 14 0 7 0 7 7 0 % E
% Phe: 0 0 0 0 0 0 7 0 7 27 7 0 7 0 0 % F
% Gly: 0 14 0 0 0 0 0 7 14 7 7 14 14 0 0 % G
% His: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 7 7 0 0 0 0 0 0 7 0 0 7 % I
% Lys: 27 0 0 27 7 27 40 0 0 14 0 7 34 0 0 % K
% Leu: 14 0 14 7 7 7 0 14 0 0 0 14 0 14 7 % L
% Met: 0 0 0 0 0 0 14 0 0 0 7 0 0 0 7 % M
% Asn: 7 14 0 7 0 0 0 7 0 7 0 7 0 0 14 % N
% Pro: 14 7 7 14 7 7 0 0 0 14 27 14 0 0 0 % P
% Gln: 7 14 7 7 0 7 0 7 14 7 7 0 14 0 7 % Q
% Arg: 7 7 34 0 14 0 0 7 0 0 7 0 0 7 7 % R
% Ser: 14 0 14 7 7 40 7 34 20 7 14 0 20 0 40 % S
% Thr: 0 0 7 0 0 7 7 14 20 0 14 14 0 20 0 % T
% Val: 0 7 0 7 14 0 0 7 7 0 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _