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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 20.3
Human Site: S561 Identified Species: 31.9
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S561 L M L D M V R S F E S V D R D
Chimpanzee Pan troglodytes Q68UT7 714 79665 S561 L M L D M V R S F E S V D R D
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 V556 H A G Q L R Q V R D Q Q N L P
Dog Lupus familis XP_544857 756 84391 S603 L V L D M V R S F E S V D R E
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S561 L L L D M V R S F E S V D R E
Rat Rattus norvegicus O08679 722 80853 V548 H A G Q L R Q V R D Q Q N L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 A570 Q I K D F P K A L A K D T P I
Chicken Gallus gallus Q9IA88 798 88848 A525 V A L S S C L A G Q V M T G S
Frog Xenopus laevis Q5XHI9 691 78470 S538 T H L N V V R S F E S V N R E
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 S855 L G E S V M G S Y N P Y L Q G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 P865 P T V A T G G P P Q R A T S Q
Sea Urchin Strong. purpuratus XP_794043 962 106011 Q627 D V T T A C F Q G K Q V N K K
Poplar Tree Populus trichocarpa XP_002306053 515 59069 F374 G G H R L P G F M D Y Q G M G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 W371 G A S P V G H W I P A H V D H
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 S487 A N M L A Q G S P A A S K I S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 0 86.6 N.A. 86.6 0 N.A. 6.6 6.6 60 13.3 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 100 26.6 100 N.A. 100 26.6 N.A. 26.6 33.3 86.6 40 N.A. N.A. N.A. 13.3 33.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 0 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 27 0 7 14 0 0 14 0 14 14 7 0 0 0 % A
% Cys: 0 0 0 0 0 14 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 34 0 0 0 0 0 20 0 7 27 7 14 % D
% Glu: 0 0 7 0 0 0 0 0 0 34 0 0 0 0 20 % E
% Phe: 0 0 0 0 7 0 7 7 34 0 0 0 0 0 0 % F
% Gly: 14 14 14 0 0 14 27 0 14 0 0 0 7 7 14 % G
% His: 14 7 7 0 0 0 7 0 0 0 0 7 0 0 7 % H
% Ile: 0 7 0 0 0 0 0 0 7 0 0 0 0 7 7 % I
% Lys: 0 0 7 0 0 0 7 0 0 7 7 0 7 7 7 % K
% Leu: 34 7 40 7 20 0 7 0 7 0 0 0 7 14 0 % L
% Met: 0 14 7 0 27 7 0 0 7 0 0 7 0 7 0 % M
% Asn: 0 7 0 7 0 0 0 0 0 7 0 0 27 0 0 % N
% Pro: 7 0 0 7 0 14 0 7 14 7 7 0 0 7 14 % P
% Gln: 7 0 0 14 0 7 14 7 0 14 20 20 0 7 7 % Q
% Arg: 0 0 0 7 0 14 34 0 14 0 7 0 0 34 0 % R
% Ser: 0 0 7 14 7 0 0 47 0 0 34 7 0 7 14 % S
% Thr: 7 7 7 7 7 0 0 0 0 0 0 0 20 0 0 % T
% Val: 7 14 7 0 20 34 0 14 0 0 7 40 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 7 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _