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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 9.39
Human Site: S605 Identified Species: 14.76
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S605 T L S P G L P S G S M S P L H
Chimpanzee Pan troglodytes Q68UT7 714 79665 S605 T L S P G L P S G S M S P L H
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 F600 F V R R N L S F R F I W P V P
Dog Lupus familis XP_544857 756 84391 P647 T L S P A L L P G S L S P L Q
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S605 T L S Q G L L S G S T S P L Q
Rat Rattus norvegicus O08679 722 80853 E592 F V R R N L N E P E S K D R V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 V614 A P W R K S P V K K V S W F G
Chicken Gallus gallus Q9IA88 798 88848 Q569 S L L P V S F Q E G R R A S D
Frog Xenopus laevis Q5XHI9 691 78470 F582 T L S P I F Q F D N T S P S K
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 P899 P L E Y R P P P Q V T P T L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 T909 L S G A P S S T G A S S Q Q Y
Sea Urchin Strong. purpuratus XP_794043 962 106011 R671 R V S L A S G R A V N L T F Q
Poplar Tree Populus trichocarpa XP_002306053 515 59069 V418 K A L Q E L N V S W K K I G Q
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 Q415 N E V L K A L Q E L N V C W K
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 A531 I A L K N L G A E W A K P S E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 13.3 66.6 N.A. 73.3 6.6 N.A. 13.3 13.3 40 20 N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: 100 100 33.3 73.3 N.A. 73.3 13.3 N.A. 20 20 46.6 20 N.A. N.A. N.A. 33.3 13.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 14 0 7 14 7 0 7 7 7 7 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 0 0 7 0 7 % D
% Glu: 0 7 7 0 7 0 0 7 20 7 0 0 0 0 7 % E
% Phe: 14 0 0 0 0 7 7 14 0 7 0 0 0 14 0 % F
% Gly: 0 0 7 0 20 0 14 0 34 7 0 0 0 7 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % H
% Ile: 7 0 0 0 7 0 0 0 0 0 7 0 7 0 0 % I
% Lys: 7 0 0 7 14 0 0 0 7 7 7 20 0 0 14 % K
% Leu: 7 47 20 14 0 54 20 0 0 7 7 7 0 34 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % M
% Asn: 7 0 0 0 20 0 14 0 0 7 14 0 0 0 0 % N
% Pro: 7 7 0 34 7 7 27 14 7 0 0 7 47 0 7 % P
% Gln: 0 0 0 14 0 0 7 14 7 0 0 0 7 7 34 % Q
% Arg: 7 0 14 20 7 0 0 7 7 0 7 7 0 7 0 % R
% Ser: 7 7 40 0 0 27 14 20 7 27 14 47 0 20 0 % S
% Thr: 34 0 0 0 0 0 0 7 0 0 20 0 14 0 0 % T
% Val: 0 20 7 0 7 0 0 14 0 14 7 7 0 7 7 % V
% Trp: 0 0 7 0 0 0 0 0 0 14 0 7 7 7 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _