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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 18.79
Human Site: S621 Identified Species: 29.52
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S621 P L H P T L V S F A H E D K N
Chimpanzee Pan troglodytes Q68UT7 714 79665 S621 P L H P T L V S F A H E D K N
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 F616 K V P G A G T F Q G K G R S T
Dog Lupus familis XP_544857 756 84391 S663 P L H P T L V S F A H E E K N
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S621 P L H S T L V S F A H E E K N
Rat Rattus norvegicus O08679 722 80853 G608 T L R P H V V G G G G T D K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 P630 S Q P E S Y E P S P C W V R E
Chicken Gallus gallus Q9IA88 798 88848 A585 S L T Q G L K A F R Q Q L R K
Frog Xenopus laevis Q5XHI9 691 78470 T598 H F N Q A S F T Y D D K S S P
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 L915 L L S P R H S L T G H A D P R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 S925 P K A P S S S S S S S T N P P
Sea Urchin Strong. purpuratus XP_794043 962 106011 T687 S T D P T V T T F V N H F Q H
Poplar Tree Populus trichocarpa XP_002306053 515 59069 P434 N M K C R W I P G T P G H H E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 C431 I G H Y N M K C R W V P G L A
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 R547 D L W T I K L R W K Y D I G N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 0 93.3 N.A. 86.6 33.3 N.A. 0 20 0 26.6 N.A. N.A. N.A. 20 20
P-Site Similarity: 100 100 6.6 100 N.A. 93.3 40 N.A. 13.3 40 26.6 26.6 N.A. N.A. N.A. 40 53.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 14 0 0 7 0 27 0 7 0 0 7 % A
% Cys: 0 0 0 7 0 0 0 7 0 0 7 0 0 0 0 % C
% Asp: 7 0 7 0 0 0 0 0 0 7 7 7 27 0 0 % D
% Glu: 0 0 0 7 0 0 7 0 0 0 0 27 14 0 20 % E
% Phe: 0 7 0 0 0 0 7 7 40 0 0 0 7 0 0 % F
% Gly: 0 7 0 7 7 7 0 7 14 20 7 14 7 7 0 % G
% His: 7 0 34 0 7 7 0 0 0 0 34 7 7 7 7 % H
% Ile: 7 0 0 0 7 0 7 0 0 0 0 0 7 0 0 % I
% Lys: 7 7 7 0 0 7 14 0 0 7 7 7 0 34 7 % K
% Leu: 7 54 0 0 0 34 7 7 0 0 0 0 7 7 0 % L
% Met: 0 7 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 7 0 7 0 0 0 0 0 7 0 7 0 34 % N
% Pro: 34 0 14 47 0 0 0 14 0 7 7 7 0 14 14 % P
% Gln: 0 7 0 14 0 0 0 0 7 0 7 7 0 7 0 % Q
% Arg: 0 0 7 0 14 0 0 7 7 7 0 0 7 14 7 % R
% Ser: 20 0 7 7 14 14 14 34 14 7 7 0 7 14 0 % S
% Thr: 7 7 7 7 34 0 14 14 7 7 0 14 0 0 7 % T
% Val: 0 7 0 0 0 14 34 0 0 7 7 0 7 0 0 % V
% Trp: 0 0 7 0 0 7 0 0 7 7 0 7 0 0 0 % W
% Tyr: 0 0 0 7 0 7 0 0 7 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _