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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 15.45
Human Site: S659 Identified Species: 24.29
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S659 G S P N C V K S R G R F P M M
Chimpanzee Pan troglodytes Q68UT7 714 79665 S659 G S P N C V K S R G R F P M M
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 N654 T T S S M E P N E M M R E I R
Dog Lupus familis XP_544857 756 84391 S701 G S P N C V K S R G R F P M M
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S659 G S P N C V K S R G R F P M M
Rat Rattus norvegicus O08679 722 80853 R646 M E P N E M M R E I R K V L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 K668 F Q P R K L G K N L P E P K H
Chicken Gallus gallus Q9IA88 798 88848 S623 S S S R A A R S A M S P F Q H
Frog Xenopus laevis Q5XHI9 691 78470 R636 L G S P N C V R S R G R F P M
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 E953 T I P Q D Y G E M L L L Q Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 T963 T A V N V T S T G M P T S S S
Sea Urchin Strong. purpuratus XP_794043 962 106011 D725 G X P D G L L D T P K S V T F
Poplar Tree Populus trichocarpa XP_002306053 515 59069 V472 G V T N S P N V V K F E V Q L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 V469 C A M T S P T V I K F E L Q L
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 K585 N N Y L V D F K F D G W E S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 0 100 N.A. 100 20 N.A. 13.3 13.3 6.6 6.6 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 100 26.6 100 N.A. 100 33.3 N.A. 20 20 6.6 13.3 N.A. N.A. N.A. 20 33.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 13.3 N.A. N.A. 0 0 N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 0 7 7 0 0 7 0 0 0 0 0 0 % A
% Cys: 7 0 0 0 27 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 7 7 0 7 0 7 0 0 0 0 7 % D
% Glu: 0 7 0 0 7 7 0 7 14 0 0 20 14 0 0 % E
% Phe: 7 0 0 0 0 0 7 0 7 0 14 27 14 0 7 % F
% Gly: 40 7 0 0 7 0 14 0 7 27 14 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % H
% Ile: 0 7 0 0 0 0 0 0 7 7 0 0 0 7 0 % I
% Lys: 0 0 0 0 7 0 27 14 0 14 7 7 0 7 0 % K
% Leu: 7 0 0 7 0 14 7 0 0 14 7 7 7 7 20 % L
% Met: 7 0 7 0 7 7 7 0 7 20 7 0 0 27 34 % M
% Asn: 7 7 0 47 7 0 7 7 7 0 0 0 0 0 0 % N
% Pro: 0 0 54 7 0 14 7 0 0 7 14 7 34 7 0 % P
% Gln: 0 7 0 7 0 0 0 0 0 0 0 0 7 27 0 % Q
% Arg: 0 0 0 14 0 0 7 14 27 7 34 14 0 0 7 % R
% Ser: 7 34 20 7 14 0 7 34 7 0 7 7 7 14 14 % S
% Thr: 20 7 7 7 0 7 7 7 7 0 0 7 0 7 0 % T
% Val: 0 7 7 0 14 27 7 14 7 0 0 0 20 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 0 7 0 0 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _