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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 17.88
Human Site: S690 Identified Species: 28.1
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 S690 A D R P L E A S L P P L Q P L
Chimpanzee Pan troglodytes Q68UT7 714 79665 S690 A D R P L E A S L P P L Q P L
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 F691 G T P G H E D F V Q W E M E V
Dog Lupus familis XP_544857 756 84391 S732 A D R P L E A S M P P L Q P M
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 S690 S E R S L D A S M S P L Q P T
Rat Rattus norvegicus O08679 722 80853 F679 G T P G H E N F V Q W E M E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 L702 S L T K D I A L G I H C E Q R
Chicken Gallus gallus Q9IA88 798 88848 S680 C P Q T S Q T S A T N G L P P
Frog Xenopus laevis Q5XHI9 691 78470 R668 G E K P L E T R M P P L H Q M
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 S1134 S D I L S Q S S L T G S Q Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A1063 Q G Q Q T A A A L A A I R E Q
Sea Urchin Strong. purpuratus XP_794043 962 106011 S800 G E V P R E F S D I R R Q R R
Poplar Tree Populus trichocarpa XP_002306053 515 59069 F499 Q R V Q G P Q F L F L D L C A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 F496 Q R V N G P Q F L F L D L C A
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 A612 D E M S T F S A Y P F L H L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 6.6 86.6 N.A. 53.3 6.6 N.A. 6.6 13.3 40 33.3 N.A. N.A. N.A. 13.3 26.6
P-Site Similarity: 100 100 20 100 N.A. 80 20 N.A. 20 26.6 66.6 53.3 N.A. N.A. N.A. 40 33.3
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 0 0 0 7 40 14 7 7 7 0 0 0 14 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 7 0 14 0 % C
% Asp: 7 27 0 0 7 7 7 0 7 0 0 14 0 0 0 % D
% Glu: 0 27 0 0 0 47 0 0 0 0 0 14 7 20 0 % E
% Phe: 0 0 0 0 0 7 7 27 0 14 7 0 0 0 0 % F
% Gly: 27 7 0 14 14 0 0 0 7 0 7 7 0 0 0 % G
% His: 0 0 0 0 14 0 0 0 0 0 7 0 14 0 0 % H
% Ile: 0 0 7 0 0 7 0 0 0 14 0 7 0 0 0 % I
% Lys: 0 0 7 7 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 7 0 7 34 0 0 7 40 0 14 40 20 7 20 % L
% Met: 0 0 7 0 0 0 0 0 20 0 0 0 14 0 14 % M
% Asn: 0 0 0 7 0 0 7 0 0 0 7 0 0 0 0 % N
% Pro: 0 7 14 34 0 14 0 0 0 34 34 0 0 34 7 % P
% Gln: 20 0 14 14 0 14 14 0 0 14 0 0 40 20 7 % Q
% Arg: 0 14 27 0 7 0 0 7 0 0 7 7 7 7 14 % R
% Ser: 20 0 0 14 14 0 14 47 0 7 0 7 0 0 0 % S
% Thr: 0 14 7 7 14 0 14 0 0 14 0 0 0 0 14 % T
% Val: 0 0 20 0 0 0 0 0 14 0 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _