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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUNK All Species: 24.24
Human Site: Y388 Identified Species: 38.1
UniProt: P57058 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57058 NP_055401.1 714 79686 Y388 L N K K L E R Y L S G K S D I
Chimpanzee Pan troglodytes Q68UT7 714 79665 Y388 L N K K L E R Y L S G K S D I
Rhesus Macaque Macaca mulatta XP_001115547 734 82154 V368 L G Y K S S E V Y G S R S S A
Dog Lupus familis XP_544857 756 84391 Y430 L N K K L E R Y L S G K S D I
Cat Felis silvestris
Mouse Mus musculus O88866 714 79585 Y388 L N K K L E R Y L S G K S D I
Rat Rattus norvegicus O08679 722 80853 T372 S S E L E G D T I T L K P R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513072 722 82227 Y392 L L K K L A K Y H K E Q K F T
Chicken Gallus gallus Q9IA88 798 88848 Y347 L L E R L K E Y R S S Q L S S
Frog Xenopus laevis Q5XHI9 691 78470 Y379 L N R K L E H Y L V N M R K P
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 Y446 S P E A M A R Y L S M R R H T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 D489 G E R K S D M D A S E I T M A
Sea Urchin Strong. purpuratus XP_794043 962 106011 D407 L A K Q R E R D E V P K I A Q
Poplar Tree Populus trichocarpa XP_002306053 515 59069 P216 A L L C G T L P F D D E N I P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 C213 V I L Y A L L C G T L P F D D
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E328 P H P E E E N E N N D S K K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 26.1 78.5 N.A. 92.4 24.6 N.A. 35.7 26.6 64.5 23.4 N.A. N.A. N.A. 21.5 30
Protein Similarity: 100 99.8 46.4 83 N.A. 95.9 44.7 N.A. 54.5 43.3 76.8 36.6 N.A. N.A. N.A. 34.5 45.2
P-Site Identity: 100 100 20 100 N.A. 100 6.6 N.A. 33.3 26.6 46.6 26.6 N.A. N.A. N.A. 13.3 33.3
P-Site Similarity: 100 100 26.6 100 N.A. 100 33.3 N.A. 46.6 53.3 53.3 46.6 N.A. N.A. N.A. 33.3 40
Percent
Protein Identity: 26.3 N.A. N.A. 25.9 24.9 N.A.
Protein Similarity: 43.2 N.A. N.A. 43.2 42.7 N.A.
P-Site Identity: 0 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 13.3 N.A. N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 7 7 14 0 0 7 0 0 0 0 7 14 % A
% Cys: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 7 7 14 0 7 14 0 0 34 14 % D
% Glu: 0 7 20 7 14 47 14 7 7 0 14 7 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % F
% Gly: 7 7 0 0 7 7 0 0 7 7 27 0 0 0 0 % G
% His: 0 7 0 0 0 0 7 0 7 0 0 0 0 7 0 % H
% Ile: 0 7 0 0 0 0 0 0 7 0 0 7 7 7 27 % I
% Lys: 0 0 40 54 0 7 7 0 0 7 0 40 14 14 0 % K
% Leu: 60 20 14 7 47 7 14 0 40 0 14 0 7 0 0 % L
% Met: 0 0 0 0 7 0 7 0 0 0 7 7 0 7 0 % M
% Asn: 0 34 0 0 0 0 7 0 7 7 7 0 7 0 0 % N
% Pro: 7 7 7 0 0 0 0 7 0 0 7 7 7 0 20 % P
% Gln: 0 0 0 7 0 0 0 0 0 0 0 14 0 0 7 % Q
% Arg: 0 0 14 7 7 0 40 0 7 0 0 14 14 7 0 % R
% Ser: 14 7 0 0 14 7 0 0 0 47 14 7 34 14 7 % S
% Thr: 0 0 0 0 0 7 0 7 0 14 0 0 7 0 14 % T
% Val: 7 0 0 0 0 0 0 7 0 14 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 7 0 0 0 54 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _