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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
20.91
Human Site:
S498
Identified Species:
38.33
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
S498
V
S
P
S
T
T
A
S
P
A
E
G
T
S
S
Chimpanzee
Pan troglodytes
XP_531484
783
84972
S498
V
S
P
S
T
T
A
S
P
A
E
G
T
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
P623
I
S
S
S
T
A
S
P
S
E
G
T
S
S
D
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
S500
V
S
S
S
A
T
A
S
P
S
E
G
T
S
S
Rat
Rattus norvegicus
Q9R1U5
776
84890
S500
V
S
S
S
A
A
V
S
P
S
E
G
T
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
S505
I
V
V
S
C
S
A
S
P
T
E
G
T
S
S
Chicken
Gallus gallus
Q9IA88
798
88848
S498
I
V
I
S
S
S
A
S
P
T
E
G
T
S
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
R550
H
T
Q
Q
L
L
K
R
P
R
G
Q
S
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
S882
G
T
T
T
S
G
Q
S
H
K
M
R
S
Y
A
Honey Bee
Apis mellifera
XP_397175
718
80391
N482
P
P
D
Y
S
G
A
N
S
F
T
S
S
L
P
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Q708
H
R
D
H
A
Q
Q
Q
Q
Y
M
N
Q
L
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
Y279
F
Q
T
H
L
P
R
Y
L
A
V
S
P
P
D
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
K400
I
K
D
M
K
A
N
K
S
V
S
D
E
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
26.6
N.A.
80
66.6
N.A.
60
60
N.A.
6.6
N.A.
6.6
6.6
0
N.A.
P-Site Similarity:
100
100
N.A.
46.6
N.A.
86.6
73.3
N.A.
73.3
80
N.A.
20
N.A.
40
26.6
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
24
24
47
0
0
24
0
0
0
0
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
24
0
0
0
0
0
0
0
0
8
0
0
24
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
47
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
16
0
0
0
0
16
47
0
0
0
% G
% His:
16
0
0
16
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
31
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
8
0
8
8
0
8
0
0
0
0
0
% K
% Leu:
0
0
0
0
16
8
0
0
8
0
0
0
0
24
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
16
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
0
8
0
0
0
% N
% Pro:
8
8
16
0
0
8
0
8
54
0
0
0
8
16
8
% P
% Gln:
0
8
8
8
0
8
16
8
8
0
0
8
8
0
0
% Q
% Arg:
0
8
0
0
0
0
8
8
0
8
0
8
0
0
0
% R
% Ser:
0
39
24
54
24
16
8
54
24
16
8
16
31
54
47
% S
% Thr:
0
16
16
8
24
24
0
0
0
16
8
8
47
0
8
% T
% Val:
31
16
8
0
0
0
8
0
0
8
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
8
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _