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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
7.27
Human Site:
S674
Identified Species:
13.33
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
S674
P
A
A
A
P
G
C
S
Q
A
P
Q
P
A
P
Chimpanzee
Pan troglodytes
XP_531484
783
84972
S674
P
A
A
A
P
G
C
S
Q
A
P
Q
P
A
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
Q799
P
A
G
P
P
G
C
Q
Q
A
A
P
L
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
Q678
A
A
A
S
S
G
C
Q
Q
G
P
Q
L
S
P
Rat
Rattus norvegicus
Q9R1U5
776
84890
Q675
S
A
V
S
S
D
Y
Q
Q
A
P
Q
L
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
P683
P
Q
A
P
A
G
I
P
P
G
P
Q
P
P
P
Chicken
Gallus gallus
Q9IA88
798
88848
C694
P
S
D
S
A
G
T
C
K
A
S
N
S
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
L887
P
S
A
L
Q
Q
A
L
L
S
P
T
P
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
P1255
F
G
H
S
L
G
P
P
P
P
P
A
P
A
P
Honey Bee
Apis mellifera
XP_397175
718
80391
V641
P
P
L
S
Q
G
H
V
D
R
D
F
D
R
E
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
S928
P
S
S
S
S
S
S
S
T
N
P
P
H
Q
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
P435
N
M
K
C
R
W
V
P
G
L
A
D
G
Q
N
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
T556
K
Y
D
I
G
N
K
T
N
T
N
E
K
I
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
46.6
N.A.
53.3
40
N.A.
46.6
20
N.A.
26.6
N.A.
33.3
13.3
20
N.A.
P-Site Similarity:
100
100
N.A.
46.6
N.A.
66.6
53.3
N.A.
46.6
40
N.A.
40
N.A.
40
20
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
39
39
16
16
0
8
0
0
39
16
8
0
24
0
% A
% Cys:
0
0
0
8
0
0
31
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
16
0
0
8
0
0
8
0
8
8
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
16
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
8
8
0
8
62
0
0
8
16
0
0
8
0
0
% G
% His:
0
0
8
0
0
0
8
0
0
0
0
0
8
0
8
% H
% Ile:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% I
% Lys:
8
0
8
0
0
0
8
0
8
0
0
0
8
0
0
% K
% Leu:
0
0
8
8
8
0
0
8
8
8
0
0
24
16
16
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
8
0
0
8
8
8
8
0
0
8
% N
% Pro:
62
8
0
16
24
0
8
24
16
8
62
16
39
8
54
% P
% Gln:
0
8
0
0
16
8
0
24
39
0
0
39
0
16
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
8
0
0
0
8
0
% R
% Ser:
8
24
8
47
24
8
8
24
0
8
8
0
8
16
0
% S
% Thr:
0
0
0
0
0
0
8
8
8
8
0
8
0
0
0
% T
% Val:
0
0
8
0
0
0
8
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _