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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WDR4 All Species: 10.3
Human Site: S356 Identified Species: 16.19
UniProt: P57081 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57081 NP_061139.2 412 45490 S356 G S A G A D A S F S S L Y K A
Chimpanzee Pan troglodytes XP_514923 412 45566 S356 G S A G A D A S F S S L Y K A
Rhesus Macaque Macaca mulatta XP_001105050 411 45737 N355 G S A G A D A N F S S L Y K A
Dog Lupus familis XP_544908 406 45137 G356 G M A G V D V G F S G L Y K A
Cat Felis silvestris
Mouse Mus musculus Q9EP82 413 45737 S358 G S V G T D D S F R S L Y K A
Rat Rattus norvegicus NP_001129139 365 40341 L318 C R D A P L A L W R P M G S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511691 493 54884 G440 G S A E M E G G F K N L Y K A
Chicken Gallus gallus XP_416749 417 46882 H366 G F V G A E S H Y S S L Y K A
Frog Xenopus laevis Q7ZY78 396 43627 S349 E G A G A P E S R F V G L Y K
Zebra Danio Brachydanio rerio A4IGH4 413 46222 Q358 G S V G L E S Q F K H L Y K V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W415 424 46480 V366 G Q P A S S G V P E G W L K M
Honey Bee Apis mellifera XP_001120270 256 29743 F209 S S L A I I S F Y N N S L L L
Nematode Worm Caenorhab. elegans Q23232 388 43620 L341 T N D A I D N L F K N V T H N
Sea Urchin Strong. purpuratus XP_001202437 434 48995 R387 G P R R R A R R W N K S K K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q03774 444 50470 S395 E Y N L N E N S F V V N N E K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 91.5 79.1 N.A. 75.3 64.8 N.A. 56.1 56.3 48.2 44.3 N.A. 27.8 24.7 25.7 32.4
Protein Similarity: 100 99.2 94.4 86.4 N.A. 83.2 74 N.A. 67.5 72.4 63.5 61 N.A. 44 38.1 42.2 52.7
P-Site Identity: 100 100 93.3 66.6 N.A. 73.3 6.6 N.A. 53.3 60 26.6 46.6 N.A. 13.3 6.6 13.3 13.3
P-Site Similarity: 100 100 100 66.6 N.A. 73.3 20 N.A. 66.6 80 26.6 60 N.A. 20 33.3 33.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 40 27 34 7 27 0 0 0 0 0 0 0 47 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 14 0 0 40 7 0 0 0 0 0 0 0 0 % D
% Glu: 14 0 0 7 0 27 7 0 0 7 0 0 0 7 7 % E
% Phe: 0 7 0 0 0 0 0 7 60 7 0 0 0 0 0 % F
% Gly: 67 7 0 54 0 0 14 14 0 0 14 7 7 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 7 0 0 7 0 % H
% Ile: 0 0 0 0 14 7 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 20 7 0 7 67 14 % K
% Leu: 0 0 7 7 7 7 0 14 0 0 0 54 20 7 7 % L
% Met: 0 7 0 0 7 0 0 0 0 0 0 7 0 0 7 % M
% Asn: 0 7 7 0 7 0 14 7 0 14 20 7 7 0 7 % N
% Pro: 0 7 7 0 7 7 0 0 7 0 7 0 0 0 0 % P
% Gln: 0 7 0 0 0 0 0 7 0 0 0 0 0 0 0 % Q
% Arg: 0 7 7 7 7 0 7 7 7 14 0 0 0 0 7 % R
% Ser: 7 47 0 0 7 7 20 34 0 34 34 14 0 7 0 % S
% Thr: 7 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % T
% Val: 0 0 20 0 7 0 7 7 0 7 14 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 14 0 0 7 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 14 0 0 0 54 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _