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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLDN2 All Species: 8.18
Human Site: S192 Identified Species: 20
UniProt: P57739 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P57739 NP_065117.1 230 24549 S192 C S S Q R N R S N Y Y D A Y Q
Chimpanzee Pan troglodytes XP_521208 197 20893 I160 P D S M K F E I G E A L Y L G
Rhesus Macaque Macaca mulatta XP_001093972 230 24518 S192 C S S Q R N R S N Y Y D A Y Q
Dog Lupus familis XP_544876 237 25129 G192 C L D E V P S G P H Q V P P R
Cat Felis silvestris
Mouse Mus musculus O88552 230 24465 T192 C S P Q G N R T N Y Y D G Y Q
Rat Rattus norvegicus Q5QT56 224 23297 G179 A G L A I L G G S F L C C T C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512437 235 24858 V192 C Q R E A P R V P Y Q L P P R
Chicken Gallus gallus XP_420271 227 24295 D189 C A S C P P R D P S G P Y S P
Frog Xenopus laevis NP_001086045 236 25557 P192 S C Q K D S T P L P Y T P Q R
Zebra Danio Brachydanio rerio Q9YH91 208 22187 A170 S L F I G W C A S G L L L L G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.6 99.1 45.5 N.A. 91.3 38.2 N.A. 47.6 69.1 44.4 39.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 85.6 99.5 64.1 N.A. 96 58.7 N.A. 62.9 81.3 62.7 60 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 6.6 N.A. 73.3 0 N.A. 20 20 6.6 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 100 26.6 N.A. 80 13.3 N.A. 33.3 26.6 26.6 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 10 0 0 10 0 0 10 0 20 0 0 % A
% Cys: 60 10 0 10 0 0 10 0 0 0 0 10 10 0 10 % C
% Asp: 0 10 10 0 10 0 0 10 0 0 0 30 0 0 0 % D
% Glu: 0 0 0 20 0 0 10 0 0 10 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 10 0 0 0 10 0 0 0 0 0 % F
% Gly: 0 10 0 0 20 0 10 20 10 10 10 0 10 0 20 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 10 10 0 0 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 20 10 0 0 10 0 0 10 0 20 30 10 20 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 30 0 0 30 0 0 0 0 0 0 % N
% Pro: 10 0 10 0 10 30 0 10 30 10 0 10 30 20 10 % P
% Gln: 0 10 10 30 0 0 0 0 0 0 20 0 0 10 30 % Q
% Arg: 0 0 10 0 20 0 50 0 0 0 0 0 0 0 30 % R
% Ser: 20 30 40 0 0 10 10 20 20 10 0 0 0 10 0 % S
% Thr: 0 0 0 0 0 0 10 10 0 0 0 10 0 10 0 % T
% Val: 0 0 0 0 10 0 0 10 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 40 40 0 20 30 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _