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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN2
All Species:
14.85
Human Site:
S223
Identified Species:
36.3
UniProt:
P57739
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57739
NP_065117.1
230
24549
S223
K
V
K
S
E
F
N
S
Y
S
L
T
G
Y
V
Chimpanzee
Pan troglodytes
XP_521208
197
20893
Rhesus Macaque
Macaca mulatta
XP_001093972
230
24518
S223
K
V
K
S
E
F
N
S
Y
S
L
T
G
Y
V
Dog
Lupus familis
XP_544876
237
25129
A223
K
D
N
R
A
P
S
A
T
S
A
S
L
S
G
Cat
Felis silvestris
Mouse
Mus musculus
O88552
230
24465
S223
K
A
K
S
E
F
N
S
Y
S
L
T
G
Y
V
Rat
Rattus norvegicus
Q5QT56
224
23297
P210
P
S
T
A
A
R
E
P
V
V
K
L
S
T
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512437
235
24858
S223
N
Y
A
P
S
L
T
S
A
S
R
S
S
Y
R
Chicken
Gallus gallus
XP_420271
227
24295
S220
K
P
K
S
E
F
S
S
Y
N
L
T
G
Y
V
Frog
Xenopus laevis
NP_001086045
236
25557
S223
S
N
H
V
P
S
W
S
S
A
S
H
H
G
Y
Zebra Danio
Brachydanio rerio
Q9YH91
208
22187
R201
S
V
K
Y
S
A
P
R
S
A
P
G
A
Y
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.6
99.1
45.5
N.A.
91.3
38.2
N.A.
47.6
69.1
44.4
39.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
85.6
99.5
64.1
N.A.
96
58.7
N.A.
62.9
81.3
62.7
60
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
13.3
N.A.
93.3
0
N.A.
20
80
6.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
0
100
33.3
N.A.
93.3
6.6
N.A.
26.6
93.3
13.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
10
20
10
0
10
10
20
10
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
40
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
40
10
10
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
10
10
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
50
0
50
0
0
0
0
0
0
0
10
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
40
10
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
10
10
0
0
0
30
0
0
10
0
0
0
0
0
% N
% Pro:
10
10
0
10
10
10
10
10
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
10
0
10
0
0
10
0
0
0
10
% R
% Ser:
20
10
0
40
20
10
20
60
20
50
10
20
20
10
10
% S
% Thr:
0
0
10
0
0
0
10
0
10
0
0
40
0
10
0
% T
% Val:
0
30
0
10
0
0
0
0
10
10
0
0
0
0
50
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
10
0
0
0
0
40
0
0
0
0
60
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _