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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSDMD
All Species:
13.94
Human Site:
S46
Identified Species:
51.11
UniProt:
P57764
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57764
NP_079012.3
484
52801
S46
L
V
V
R
K
P
S
S
S
W
F
W
K
P
R
Chimpanzee
Pan troglodytes
XP_001152508
484
53000
S46
L
V
V
R
K
P
S
S
S
W
F
W
K
P
R
Rhesus Macaque
Macaca mulatta
XP_001085967
495
53817
S46
L
V
F
R
K
P
S
S
S
W
F
W
K
L
C
Dog
Lupus familis
XP_851732
583
63898
R161
L
L
A
R
K
L
S
R
L
W
F
W
K
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9D8T2
487
53219
S47
L
L
N
R
K
F
S
S
S
R
F
W
K
P
R
Rat
Rattus norvegicus
P85967
474
53233
S45
I
L
Q
K
T
P
Q
S
L
F
F
K
S
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505287
446
48775
G46
L
V
L
R
K
R
K
G
T
L
F
W
G
A
R
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.7
77.3
50.7
N.A.
57.7
29.5
N.A.
36.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.1
83.6
60
N.A.
73.5
49.5
N.A.
50.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
66.6
N.A.
73.3
20
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
80
73.3
N.A.
80
46.6
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
0
0
0
0
0
0
0
0
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% E
% Phe:
0
0
15
0
0
15
0
0
0
15
100
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
15
0
0
0
0
15
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
15
86
0
15
0
0
0
0
15
72
0
0
% K
% Leu:
86
43
15
0
0
15
0
0
29
15
0
0
0
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
58
0
0
0
0
0
0
0
58
0
% P
% Gln:
0
0
15
0
0
0
15
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
86
0
15
0
15
0
15
0
0
0
0
72
% R
% Ser:
0
0
0
0
0
0
72
72
58
0
0
0
15
0
0
% S
% Thr:
0
0
0
0
15
0
0
0
15
0
0
0
0
0
0
% T
% Val:
0
58
29
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
58
0
86
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _