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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTPN All Species: 13.64
Human Site: Y21 Identified Species: 33.33
UniProt: P58546 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P58546 NP_665807.1 118 12895 Y21 D L D E V K D Y V A K G E D V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus NP_032124 118 12842 Y21 D L D E V K D Y V A K G E D V
Rat Rattus norvegicus P62775 118 12842 Y21 D L D E V K D Y V A K G E D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q91955 118 12867 Y21 D L D E V K D Y V A K G E D V
Frog Xenopus laevis Q7T0Q1 118 12726 F21 D L D A V K E F V A G G V D V
Zebra Danio Brachydanio rerio Q7T2B9 118 12730 I21 D L D E V K N I L V K A E D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_723568 121 13328 A24 E F D A V Q D A F Q N D A Q K
Honey Bee Apis mellifera XP_623750 118 13072 I19 D L E Q V R D I V E N K N I D
Nematode Worm Caenorhab. elegans NP_508437 114 12530 K16 N G E I D A V K Q S V N E K N
Sea Urchin Strong. purpuratus XP_792242 118 12942 K15 A Q N G D V S K L Q E L Q F D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 99.1 99.1 N.A. N.A. 97.4 80.5 79.6 N.A. 49.5 52.5 41.5 41.5
Protein Similarity: 100 N.A. N.A. N.A. N.A. 99.1 99.1 N.A. N.A. 98.3 86.4 88.9 N.A. 66.9 68.6 59.3 66.1
P-Site Identity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. N.A. 100 66.6 66.6 N.A. 20 33.3 6.6 0
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. N.A. 100 80 80 N.A. 33.3 53.3 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 20 0 10 0 10 0 50 0 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 70 0 70 0 20 0 60 0 0 0 0 10 0 60 20 % D
% Glu: 10 0 20 50 0 0 10 0 0 10 10 0 60 0 0 % E
% Phe: 0 10 0 0 0 0 0 10 10 0 0 0 0 10 0 % F
% Gly: 0 10 0 10 0 0 0 0 0 0 10 50 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 20 0 0 0 0 0 10 0 % I
% Lys: 0 0 0 0 0 60 0 20 0 0 50 10 0 10 10 % K
% Leu: 0 70 0 0 0 0 0 0 20 0 0 10 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 0 0 10 0 0 0 20 10 10 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 0 10 0 10 0 0 10 20 0 0 10 10 0 % Q
% Arg: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 80 10 10 0 60 10 10 0 10 0 60 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 40 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _